Casp4 - caspase 4, apoptosis-related cysteine peptidase Gene

Also Known as Caspl; ich-3; CASP-4; Casp11; CASP-11

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12363

About Casp4

Chromosome 9: 5,308,828-5,336,783 forward strand.GRCm39:CM001002.3

This gene has 7 transcripts (splice variants), 252 orthologues, 11 paralogues and is associated with 21 phenotypes. Biased expression in large intestine adult (RPKM 7.7), bladder adult (RPKM 4.) and 14 other tissues.

Summary

This gene encodes a member of the cysteine proteases that plays important roles in Apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon Bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called Caspase 11. This gene is present in a cluster of three Caspase genes on chromosome 9. [provided by RefSeq, Apr 2015]

Casp4 Products (8)

mRNA Protein Name
NM_001379320.1 NP_001366249.1 caspase-4 isoform 4
NM_001379318.1 NP_001366247.1 caspase-4 isoform 2
NM_001379319.1 NP_001366248.1 caspase-4 isoform 3
NM_001379321.1 NP_001366250.1 caspase-4 isoform 5
NM_001379323.1 NP_001366252.1 caspase-4 isoform 7
NM_007609.3 NP_031635.2 caspase-4 isoform 1
NM_001379322.1 NP_001366251.1 caspase-4 isoform 6
NM_001379321.1 NP_001366250.1 caspase-4 isoform 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
30135078 MGI
enables cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
30392956 MGI
enables lipid binding IDA
IDA: Inferred from direct assay
25119034 MGI
enables lipopolysaccharide binding IDA
IDA: Inferred from direct assay
25119034 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
30692621 MGI
Biological Process GO Annotation Evidence References Source
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
30392956 MGI
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
25119034 MGI
involved in defense response to bacterium IMP
IMP: Inferred from mutant phenotype
23348507 MGI
involved in detection of lipopolysaccharide IDA
IDA: Inferred from direct assay
23887873 MGI
acts upstream of or within ectopic germ cell programmed cell death IGI
IGI: Inferred from genetic interaction
11536012 MGI
acts upstream of or within ectopic germ cell programmed cell death IMP
IMP: Inferred from mutant phenotype
11536012 MGI
acts upstream of interleukin-1 beta production IGI
IGI: Inferred from genetic interaction
22002608 MGI
acts upstream of macrophage cytokine production IGI
IGI: Inferred from genetic interaction
22002608 MGI
involved in non-canonical inflammasome complex assembly IDA
IDA: Inferred from direct assay
23887873 MGI
involved in non-canonical inflammasome complex assembly IMP
IMP: Inferred from mutant phenotype
22895188 MGI
involved in positive regulation of NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
26173909 MGI
involved in positive regulation of inflammatory response IDA
IDA: Inferred from direct assay
30392956 MGI
involved in positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
23348507 MGI
acts upstream of or within positive regulation of interleukin-1 beta production IGI
IGI: Inferred from genetic interaction
22002608 MGI
involved in positive regulation of interleukin-18-mediated signaling pathway IDA
IDA: Inferred from direct assay
30392956 MGI
acts upstream of or within positive regulation of macrophage cytokine production IGI
IGI: Inferred from genetic interaction
22002608 MGI
involved in protein autoprocessing IDA
IDA: Inferred from direct assay
32109412 MGI
involved in protein autoprocessing IMP
IMP: Inferred from mutant phenotype
30392956 MGI
involved in protein maturation IDA
IDA: Inferred from direct assay
30135078 MGI
involved in pyroptotic cell death IDA
IDA: Inferred from direct assay
38632402 MGI
involved in pyroptotic inflammatory response IDA
IDA: Inferred from direct assay
30135078 MGI
acts upstream of or within pyroptotic inflammatory response IMP
IMP: Inferred from mutant phenotype
22002608 MGI
involved in pyroptotic inflammatory response IMP
IMP: Inferred from mutant phenotype
23348507 MGI
involved in regulation of inflammatory response IDA
IDA: Inferred from direct assay
32109412 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
16670335 MGI
is active in cytosol IDA
IDA: Inferred from direct assay
16670335 MGI
part of non-canonical inflammasome complex IDA
IDA: Inferred from direct assay
23887873 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp4 Protein Structure

CARD_CASP1-like

CARD_CASP1-like: cd08325 (4 - 84)

CASc

CASc: smart00115 (121 - 370)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
Protein Preferred Names Protein Names

caspase-4

  • caspase 11, apoptosis-related cysteine peptidase

  • caspase 11, apoptosis-related cysteine protease

  • caspase 4, apoptosis-related cysteine protease

  • caspase-11 short form splicing

  • protease ICH-3

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18678A Bremelanotide Acetate Agonist 99.97% Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01955 CASP4 Human Pre-designed siRNA Set A / Unkown
HY-RS01956 Casp4 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01957 Casp4 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp4 NCBI NCBI:837