2. Gene
  3. Casp4 - caspase 4, apoptosis-related cysteine peptidase Gene

Casp4 - caspase 4, apoptosis-related cysteine peptidase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Caspl; ich-3; CASP-4; Casp11; CASP-11

Gene ID: 12363 | Gene type: protein coding

About Casp4

Chromosome 9: 5,308,828-5,336,783 forward strand.GRCm39:CM001002.3

This gene has 7 transcripts (splice variants), 252 orthologues, 11 paralogues and is associated with 21 phenotypes. Biased expression in large intestine adult (RPKM 7.7), bladder adult (RPKM 4.) and 14 other tissues.

Summary

This gene encodes a member of the cysteine proteases that plays important roles in Apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon Bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called Caspase 11. This gene is present in a cluster of three Caspase genes on chromosome 9. [provided by RefSeq, Apr 2015]

Casp4 Products(7)

mRNA Protein Name
NM_001379320.1 NP_001366249.1 caspase-4 isoform 4
NM_001379318.1 NP_001366247.1 caspase-4 isoform 2
NM_001379319.1 NP_001366248.1 caspase-4 isoform 3
NM_001379321.1 NP_001366250.1 caspase-4 isoform 5
NM_001379323.1 NP_001366252.1 caspase-4 isoform 7
NM_007609.3 NP_031635.2 caspase-4 isoform 1
NM_001379322.1 NP_001366251.1 caspase-4 isoform 6

Casp4 Protein Structure

CARD_CASP1-like

CARD_CASP1-like: cd08325 (4 - 84)

CASc

CASc: smart00115 (121 - 370)

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  • 373 a.a.
Protein Preferred Names Protein Names

caspase-4

caspase 11, apoptosis-related cysteine peptidase

caspase 11, apoptosis-related cysteine protease

caspase 4, apoptosis-related cysteine protease

caspase-11 short form splicing

protease ICH-3

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01955 CASP4 Human Pre-designed siRNA Set A / Unkown
HY-RS01956 Casp4 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01957 Casp4 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp4 NCBI NCBI:837