Runx3 - runt related transcription factor 3 Gene

Also Known as Rx3; AML2; Cbfa3; Pebp2a3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12399

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of epithelial cell proliferation; negative regulation of transcription by RNA polymerase II; and regulation of alpha-beta T cell differentiation. Acts upstream of or within several processes, including chondrocyte differentiation; hair follicle morphogenesis; and positive regulation of extrinsic apoptotic signaling pathway. Located in chromatin and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Used to study asthma and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including breast Cancer (multiple); female reproductive organ Cancer (multiple); lung non-small cell carcinoma; pancreatic cancer; and urinary bladder Cancer. Orthologous to human RUNX3 (RUNX family transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Runx3 Products (2)

mRNA Protein Name
NM_001369050.1 NP_001355979.1 runt-related transcription factor 3 isoform 2
NM_019732.2 NP_062706.2 runt-related transcription factor 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12807883 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17352693 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17352693 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20399120 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
12352981 MGI
acts upstream of or within cell maturation IGI
IGI: Inferred from genetic interaction
15107406 MGI
acts upstream of or within chondrocyte differentiation IGI
IGI: Inferred from genetic interaction
22916278 MGI
acts upstream of or within hair follicle morphogenesis IMP
IMP: Inferred from mutant phenotype
15937937 MGI
involved in negative regulation of CD4-positive, alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
18258917 MGI
involved in negative regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
11955451 MGI
involved in negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
11955451 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17352693 MGI
acts upstream of or within neuron projection development IMP
IMP: Inferred from mutant phenotype
12352981 MGI
involved in positive regulation of CD8-positive, alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
18258917 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
11955451 MGI
acts upstream of or within type II interferon production IDA
IDA: Inferred from direct assay
20399120 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
17352693 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15514019 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

runt-related transcription factor 3

  • CBF-alpha-3

  • PEA2-alpha C

  • PEBP2-alpha C

  • SL3-3 enhancer factor 1 alpha C subunit

  • SL3/AKV core-binding factor alpha C subunit

  • acute myeloid leukemia 2 protein

  • core binding factor alpha 3

  • core-binding factor subunit alpha-3

  • oncogene AML-2

  • polyomaviru

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12352 RUNX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20100 Runx3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26603 Runx3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Runx3 NCBI NCBI:864