Cbx4 - chromobox 4 Gene

Also Known as PC2; MPc2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12418

Summary

Enables several functions, including SUMO binding activity; SUMO transferase activity; and nucleic acid binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and protein sumoylation. Located in nuclear body. Is expressed in several structures, including adrenal gland; brain; gut; lung; and thymus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CBX4 (chromobox 4). [provided by Alliance of Genome Resources, Apr 2022]

Cbx4 Products (1)

mRNA Protein Name
NM_007625.2 NP_031651.2 E3 SUMO-protein ligase CBX4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SUMO binding IDA
IDA: Inferred from direct assay
20176810 MGI
enables SUMO transferase activity EXP
EXP: Inferred from Experiment
17439403 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
17392792 MGI
enables methylated histone binding IDA
IDA: Inferred from direct assay
16537902 MGI
enables phosphoprotein binding IPI
IPI: Inferred from physical interaction
9367786 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9367786 MGI
enables single-stranded RNA binding IDA
IDA: Inferred from direct assay
16537902 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
20417598 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9367786 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
20417598 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17392792 MGI
acts upstream of or within protein sumoylation IMP
IMP: Inferred from mutant phenotype
20176810 MGI
Cellular Component GO Annotation Evidence References Source
located in nuclear body IDA
IDA: Inferred from direct assay
20417598 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16537902 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 SUMO-protein ligase CBX4

  • E3 SUMO-protein transferase CBX4

  • chromobox homolog 4

  • chromobox protein homolog 4

  • polycomb 2 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15476 VU 0364439 99.42% Unkown
HY-178918 XZA-1 99.59% Unkown
HY-RS02011 CBX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181089 CBX2-IN-1 Inhibitor / Unkown
HY-RS20702 Cbx4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27213 Cbx4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cbx4 NCBI NCBI:8535