Cd2ap - CD2-associated protein Gene

Also Known as Mets1; METS-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12488

Summary

This gene encodes a scaffolding molecule that regulates the actin Cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. The mouse genome contains at least two pseudogenes located on chromosomes 9 and 17. [provided by RefSeq, Jul 2008]

Cd2ap Products (4)

mRNA Protein Name
NM_001410466.1 NP_001397395.1 CD2-associated protein isoform 2
NM_001410467.1 NP_001397396.1 CD2-associated protein isoform 3
NM_001410468.1 NP_001397397.1 CD2-associated protein isoform 4
NM_009847.4 NP_033977.3 CD2-associated protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
15956777 MGI
enables actin filament binding IDA
IDA: Inferred from direct assay
17606992 MGI
enables clathrin binding IDA
IDA: Inferred from direct assay
26546360 MGI
enables phosphatidylinositol 3-kinase regulatory subunit binding IDA
IDA: Inferred from direct assay
27076424 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10913159 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within D-glucose import IMP
IMP: Inferred from mutant phenotype
26546360 MGI
acts upstream of or within ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
28878342 MGI
acts upstream of or within Rab protein signal transduction IMP
IMP: Inferred from mutant phenotype
27076424 MGI
acts upstream of or within T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
14512504 MGI
acts upstream of or within actin filament polymerization IMP
IMP: Inferred from mutant phenotype
24218450 MGI
acts upstream of or within adipose tissue development IDA
IDA: Inferred from direct assay
29729186 MGI
acts upstream of or within apoptotic process IGI
IGI: Inferred from genetic interaction
28878342 MGI
acts upstream of or within apoptotic process IMP
IMP: Inferred from mutant phenotype
14512504 MGI
acts upstream of or within cell differentiation IGI
IGI: Inferred from genetic interaction
19013146 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
19679673 MGI
acts upstream of or within cell-cell adhesion mediated by cadherin IGI
IGI: Inferred from genetic interaction
19013146 MGI
acts upstream of or within cell-cell junction organization IGI
IGI: Inferred from genetic interaction
19013146 MGI
acts upstream of or within cell-cell junction organization IMP
IMP: Inferred from mutant phenotype
25968128 MGI
acts upstream of or within collateral sprouting IMP
IMP: Inferred from mutant phenotype
27076424 MGI
acts upstream of or within endothelium development IMP
IMP: Inferred from mutant phenotype
25968128 MGI
acts upstream of or within filopodium assembly IMP
IMP: Inferred from mutant phenotype
27076424 MGI
acts upstream of or within gene expression IGI
IGI: Inferred from genetic interaction
28878342 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
15213232 MGI
acts upstream of or within glomerulus development IMP
IMP: Inferred from mutant phenotype
25968128 MGI
acts upstream of or within immunological synapse formation IMP
IMP: Inferred from mutant phenotype
14512504 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
14512504 MGI
acts upstream of or within kidney development IDA
IDA: Inferred from direct assay
15213232 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
15213232 MGI
acts upstream of or within lipid metabolic process IDA
IDA: Inferred from direct assay
29729186 MGI
acts upstream of or within liver development IDA
IDA: Inferred from direct assay
29729186 MGI
acts upstream of or within localization of cell IGI
IGI: Inferred from genetic interaction
19013146 MGI
acts upstream of or within lymph node development IMP
IMP: Inferred from mutant phenotype
24218450 MGI
acts upstream of or within maintenance of blood-brain barrier IMP
IMP: Inferred from mutant phenotype
26358779 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
15213232 MGI
acts upstream of or within membrane organization IMP
IMP: Inferred from mutant phenotype
25968128 MGI
acts upstream of or within negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
18753381 MGI
acts upstream of or within negative regulation of transforming growth factor beta1 production IGI
IGI: Inferred from genetic interaction
21911934 MGI
acts upstream of or within nerve growth factor signaling pathway IMP
IMP: Inferred from mutant phenotype
27076424 MGI
acts upstream of or within neuron projection development IMP
IMP: Inferred from mutant phenotype
27076424 MGI
acts upstream of or within neurotrophin TRK receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
27076424 MGI
acts upstream of or within neurotrophin signaling pathway IMP
IMP: Inferred from mutant phenotype
27076424 MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
28878342 MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
15213232 MGI
acts upstream of or within podocyte differentiation IMP
IMP: Inferred from mutant phenotype
25968128 MGI
acts upstream of or within positive regulation of protein localization to nucleus IGI
IGI: Inferred from genetic interaction
21911934 MGI
acts upstream of or within protein catabolic process IDA
IDA: Inferred from direct assay
18753381 MGI
acts upstream of or within protein catabolic process IMP
IMP: Inferred from mutant phenotype
14512504 MGI
acts upstream of or within protein heterooligomerization IDA
IDA: Inferred from direct assay
17606992 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
14512504 MGI
acts upstream of or within protein secretion IMP
IMP: Inferred from mutant phenotype
22809625 MGI
acts upstream of or within protein transport IMP
IMP: Inferred from mutant phenotype
26546360 MGI
acts upstream of or within regulation of actin cytoskeleton organization IGI
IGI: Inferred from genetic interaction
21911934 MGI
acts upstream of or within regulation of protein binding IDA
IDA: Inferred from direct assay
27076424 MGI
acts upstream of or within regulation of protein binding IMP
IMP: Inferred from mutant phenotype
19679673 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
27076424 MGI
acts upstream of or within renal albumin absorption IMP
IMP: Inferred from mutant phenotype
30612599 MGI
acts upstream of or within response to glial cell derived neurotrophic factor IDA
IDA: Inferred from direct assay
18753381 MGI
acts upstream of or within response to insulin IMP
IMP: Inferred from mutant phenotype
26546360 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
28878342 MGI
acts upstream of or within response to transforming growth factor beta IMP
IMP: Inferred from mutant phenotype
15213232 MGI
acts upstream of or within response to virus IDA
IDA: Inferred from direct assay
29729186 MGI
acts upstream of or within response to wounding IMP
IMP: Inferred from mutant phenotype
27076424 MGI
acts upstream of or within stress-activated MAPK cascade IMP
IMP: Inferred from mutant phenotype
15213232 MGI
involved in synapse organization IDA
IDA: Inferred from direct assay
31412248 MGI
involved in synapse organization IEP
IEP: Inferred from expression pattern
31412248 MGI
involved in synapse organization IMP
IMP: Inferred from mutant phenotype
31412248 MGI
acts upstream of transforming growth factor beta1 production IGI
IGI: Inferred from genetic interaction
21911934 MGI
Cellular Component GO Annotation Evidence References Source
is active in actin filament IDA
IDA: Inferred from direct assay
17606992 MGI
located in axon IDA
IDA: Inferred from direct assay
32552912 MGI
is active in cell periphery IDA
IDA: Inferred from direct assay
16501493 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
10913159 MGI
located in dendrite IDA
IDA: Inferred from direct assay
32552912 MGI
is active in growth cone IMP
IMP: Inferred from mutant phenotype
27076424 MGI
is active in late endosome IDA
IDA: Inferred from direct assay
15956777 MGI
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
31412248 MGI
is active in neuromuscular junction IEP
IEP: Inferred from expression pattern
31412248 MGI
is active in neuromuscular junction IMP
IMP: Inferred from mutant phenotype
31412248 MGI
is active in neuron projection IMP
IMP: Inferred from mutant phenotype
27076424 MGI
is active in nuclear envelope lumen IDA
IDA: Inferred from direct assay
26546360 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15924139 MGI
is active in podosome IDA
IDA: Inferred from direct assay
17606992 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
27076424 MGI
is active in slit diaphragm IDA
IDA: Inferred from direct assay
11733379 MGI
is active in trans-Golgi network membrane IDA
IDA: Inferred from direct assay
26546360 MGI
is active in vesicle IDA
IDA: Inferred from direct assay
15956777 MGI
located in vesicle IDA
IDA: Inferred from direct assay
32552912 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CD2-associated protein

  • SH3 domain-containing adapter protein

  • SH3 domain-containing adaptor protein METS-1

  • mesenchyme to epithelium transition protein, SH3 domains

  • mesenchyme-to-epithelium transition protein with SH3 domains 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02224 CD2AP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21509 Cd2ap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28027 Cd2ap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd2ap NCBI NCBI:23607