Cd2ap - CD2-associated protein Gene

Mus musculus

Also known as Mets1; METS-1

Gene ID: 12488 | Gene type: protein coding

About Cd2ap

Summary

This gene encodes a scaffolding molecule that regulates the actin Cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. The mouse genome contains at least two pseudogenes located on chromosomes 9 and 17. [provided by RefSeq, Jul 2008]

Cd2ap Products(4)

mRNA	Protein	Name
NM_001410466.1	NP_001397395.1	CD2-associated protein isoform 2
NM_001410467.1	NP_001397396.1	CD2-associated protein isoform 3
NM_001410468.1	NP_001397397.1	CD2-associated protein isoform 4
NM_009847.4	NP_033977.3	CD2-associated protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	15956777	MGI
enables actin filament binding	IDA IDA: Inferred from direct assay	17606992	MGI
enables clathrin binding	IDA IDA: Inferred from direct assay	26546360	MGI
enables phosphatidylinositol 3-kinase regulatory subunit binding	IDA IDA: Inferred from direct assay	27076424	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10913159	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within D-glucose import	IMP IMP: Inferred from mutant phenotype	26546360	MGI
acts upstream of or within ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	28878342	MGI
acts upstream of or within Rab protein signal transduction	IMP IMP: Inferred from mutant phenotype	27076424	MGI
acts upstream of or within T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	14512504	MGI
acts upstream of or within actin filament polymerization	IMP IMP: Inferred from mutant phenotype	24218450	MGI
acts upstream of or within adipose tissue development	IDA IDA: Inferred from direct assay	29729186	MGI
acts upstream of or within apoptotic process	IGI IGI: Inferred from genetic interaction	28878342	MGI
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	14512504	MGI
acts upstream of or within cell differentiation	IGI IGI: Inferred from genetic interaction	19013146	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	19679673	MGI
acts upstream of or within cell-cell adhesion mediated by cadherin	IGI IGI: Inferred from genetic interaction	19013146	MGI
acts upstream of or within cell-cell junction organization	IGI IGI: Inferred from genetic interaction	19013146	MGI
acts upstream of or within cell-cell junction organization	IMP IMP: Inferred from mutant phenotype	25968128	MGI
acts upstream of or within collateral sprouting	IMP IMP: Inferred from mutant phenotype	27076424	MGI
acts upstream of or within endothelium development	IMP IMP: Inferred from mutant phenotype	25968128	MGI
acts upstream of or within filopodium assembly	IMP IMP: Inferred from mutant phenotype	27076424	MGI
acts upstream of or within gene expression	IGI IGI: Inferred from genetic interaction	28878342	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	15213232	MGI
acts upstream of or within glomerulus development	IMP IMP: Inferred from mutant phenotype	25968128	MGI
acts upstream of or within immunological synapse formation	IMP IMP: Inferred from mutant phenotype	14512504	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	14512504	MGI
acts upstream of or within kidney development	IDA IDA: Inferred from direct assay	15213232	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	15213232	MGI
acts upstream of or within lipid metabolic process	IDA IDA: Inferred from direct assay	29729186	MGI
acts upstream of or within liver development	IDA IDA: Inferred from direct assay	29729186	MGI
acts upstream of or within localization of cell	IGI IGI: Inferred from genetic interaction	19013146	MGI
acts upstream of or within lymph node development	IMP IMP: Inferred from mutant phenotype	24218450	MGI
acts upstream of or within maintenance of blood-brain barrier	IMP IMP: Inferred from mutant phenotype	26358779	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	15213232	MGI
acts upstream of or within membrane organization	IMP IMP: Inferred from mutant phenotype	25968128	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	18753381	MGI
acts upstream of or within negative regulation of transforming growth factor beta1 production	IGI IGI: Inferred from genetic interaction	21911934	MGI
acts upstream of or within nerve growth factor signaling pathway	IMP IMP: Inferred from mutant phenotype	27076424	MGI
acts upstream of or within neuron projection development	IMP IMP: Inferred from mutant phenotype	27076424	MGI
acts upstream of or within neurotrophin TRK receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	27076424	MGI
acts upstream of or within neurotrophin signaling pathway	IMP IMP: Inferred from mutant phenotype	27076424	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	28878342	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	15213232	MGI
acts upstream of or within podocyte differentiation	IMP IMP: Inferred from mutant phenotype	25968128	MGI
acts upstream of or within positive regulation of protein localization to nucleus	IGI IGI: Inferred from genetic interaction	21911934	MGI
acts upstream of or within protein catabolic process	IDA IDA: Inferred from direct assay	18753381	MGI
acts upstream of or within protein catabolic process	IMP IMP: Inferred from mutant phenotype	14512504	MGI
acts upstream of or within protein heterooligomerization	IDA IDA: Inferred from direct assay	17606992	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	14512504	MGI
acts upstream of or within protein secretion	IMP IMP: Inferred from mutant phenotype	22809625	MGI
acts upstream of or within protein transport	IMP IMP: Inferred from mutant phenotype	26546360	MGI
acts upstream of or within regulation of actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	21911934	MGI
acts upstream of or within regulation of protein binding	IDA IDA: Inferred from direct assay	27076424	MGI
acts upstream of or within regulation of protein binding	IMP IMP: Inferred from mutant phenotype	19679673	MGI
acts upstream of or within regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	27076424	MGI
acts upstream of or within renal albumin absorption	IMP IMP: Inferred from mutant phenotype	30612599	MGI
acts upstream of or within response to glial cell derived neurotrophic factor	IDA IDA: Inferred from direct assay	18753381	MGI
acts upstream of or within response to insulin	IMP IMP: Inferred from mutant phenotype	26546360	MGI
acts upstream of or within response to oxidative stress	IMP IMP: Inferred from mutant phenotype	28878342	MGI
acts upstream of or within response to transforming growth factor beta	IMP IMP: Inferred from mutant phenotype	15213232	MGI
acts upstream of or within response to virus	IDA IDA: Inferred from direct assay	29729186	MGI
acts upstream of or within response to wounding	IMP IMP: Inferred from mutant phenotype	27076424	MGI
acts upstream of or within stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	15213232	MGI
involved in synapse organization	IDA IDA: Inferred from direct assay	31412248	MGI
involved in synapse organization	IEP IEP: Inferred from expression pattern	31412248	MGI
involved in synapse organization	IMP IMP: Inferred from mutant phenotype	31412248	MGI
acts upstream of transforming growth factor beta1 production	IGI IGI: Inferred from genetic interaction	21911934	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in actin filament	IDA IDA: Inferred from direct assay	17606992	MGI
located in axon	IDA IDA: Inferred from direct assay	32552912	MGI
is active in cell periphery	IDA IDA: Inferred from direct assay	16501493	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10913159	MGI
located in dendrite	IDA IDA: Inferred from direct assay	32552912	MGI
is active in growth cone	IMP IMP: Inferred from mutant phenotype	27076424	MGI
is active in late endosome	IDA IDA: Inferred from direct assay	15956777	MGI
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	31412248	MGI
is active in neuromuscular junction	IEP IEP: Inferred from expression pattern	31412248	MGI
is active in neuromuscular junction	IMP IMP: Inferred from mutant phenotype	31412248	MGI
is active in neuron projection	IMP IMP: Inferred from mutant phenotype	27076424	MGI
is active in nuclear envelope lumen	IDA IDA: Inferred from direct assay	26546360	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15924139	MGI
is active in podosome	IDA IDA: Inferred from direct assay	17606992	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	27076424	MGI
is active in slit diaphragm	IDA IDA: Inferred from direct assay	11733379	MGI
is active in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	26546360	MGI
is active in vesicle	IDA IDA: Inferred from direct assay	15956777	MGI
located in vesicle	IDA IDA: Inferred from direct assay	32552912	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

CD2-associated protein

SH3 domain-containing adapter protein	SH3 domain-containing adaptor protein METS-1
mesenchyme to epithelium transition protein, SH3 domains	mesenchyme-to-epithelium transition protein with SH3 domains 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02224	CD2AP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21509	Cd2ap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28027	Cd2ap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd2ap	NCBI	NCBI:23607

Name
Email *

	Sorry, but the email address you supplied was invalid.