Cd59a - CD59a antigen Gene

Also Known as Cd59; protectin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12509

Summary

Predicted to enable complement binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of Fibroblast Growth Factor production; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Acts upstream of or within negative regulation of activation of membrane attack complex. Located in external side of plasma membrane. Is expressed in several structures, including Meckel's cartilage; nervous system; neural retina; skeleton; and testis. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian Cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Cd59a Products (2)

mRNA Protein Name
NM_001111060.2 NP_001104530.1 CD59A glycoprotein precursor
NM_007652.5 NP_031678.1 CD59A glycoprotein precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of activation of membrane attack complex IDA
IDA: Inferred from direct assay
11471050 MGI
involved in negative regulation of activation of membrane attack complex IMP
IMP: Inferred from mutant phenotype
17237428 MGI
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
17237428 MGI
involved in negative regulation of complement activation IDA
IDA: Inferred from direct assay
17237428 MGI
involved in negative regulation of fibroblast growth factor production IDA
IDA: Inferred from direct assay
17237428 MGI
involved in negative regulation of vascular endothelial growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17237428 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
11471050 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
18947875 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11471050 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CD59A glycoprotein

  • CD59 antigen

  • MAC-IP

  • MAC-inhibitory protein

  • MACIF

  • membrane attack complex inhibition factor

Recombinant Cd59a Proteins

Cat. No. Product Name Accession Purity
HY-P76809 CD59a Protein, Mouse (HEK293, Fc) O55186/NP_001104530.1 (L24-K95) ≥ 90%, as determined by reducing SDS-PAGE.