Cdc45 - cell division cycle 45 Gene

Predicted to enable DNA replication origin binding activity; chromatin binding activity; and single-stranded DNA binding activity. Predicted to be involved in DNA replication initiation; double-strand break repair via break-induced replication; and mitotic DNA replication preinitiation complex assembly. Predicted to act upstream of or within DNA replication. Predicted to be located in centrosome; ciliary basal body; and nucleoplasm. Predicted to be part of DNA replication preinitiation complex. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and notochord. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Orthologous to human CDC45 (cell division cycle 45). [provided by Alliance of Genome Resources, Apr 2022]