Cdk5r1 - cyclin-dependent kinase 5, regulatory subunit 1 (p35) Gene

Also Known as p25; p35; Cdk5r; D11Bwg0379e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12569

Summary

Enables several functions, including HSP90 protein binding activity; cyclin-dependent protein serine/threonine kinase activator activity; and enzyme binding activity. Involved in several processes, including Ephrin Receptor signaling pathway; nervous system development; and regulation of Cytoskeleton organization. Acts upstream of or within several processes, including G1 to G0 transition involved in cell differentiation; nervous system development; and serine phosphorylation of STAT protein. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study attention deficit hyperactivity disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Cdk5r1 Products (1)

mRNA Protein Name
NM_009871.3 NP_034001.1 cyclin-dependent kinase 5 activator 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Hsp90 protein binding IPI
IPI: Inferred from physical interaction
17517623 MGI
enables actin binding IPI
IPI: Inferred from physical interaction
19118186 MGI
enables actin filament binding IPI
IPI: Inferred from physical interaction
19118186 MGI
enables cyclin-dependent protein serine/threonine kinase activator activity IMP
IMP: Inferred from mutant phenotype
11517264 MGI
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
19118186 MGI
enables protease binding IPI
IPI: Inferred from physical interaction
19118186 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11276227 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
19118186 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G1 to G0 transition involved in cell differentiation IMP
IMP: Inferred from mutant phenotype
21566658 MGI
involved in axon guidance IMP
IMP: Inferred from mutant phenotype
10545161 MGI
involved in axonal fasciculation IMP
IMP: Inferred from mutant phenotype
10545161 MGI
involved in brain development IMP
IMP: Inferred from mutant phenotype
10545161 MGI
acts upstream of or within cerebellum development IGI
IGI: Inferred from genetic interaction
11517264 MGI
acts upstream of or within cerebellum development IMP
IMP: Inferred from mutant phenotype
11226314 MGI
involved in cerebral cortex radially oriented cell migration IMP
IMP: Inferred from mutant phenotype
20624590 MGI
involved in ephrin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17143272 MGI
acts upstream of or within hippocampus development IGI
IGI: Inferred from genetic interaction
11517264 MGI
acts upstream of or within layer formation in cerebral cortex IGI
IGI: Inferred from genetic interaction
11517264 MGI
involved in neuron cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
10753743 MGI
involved in neuron migration IDA
IDA: Inferred from direct assay
9010203 MGI
acts upstream of or within neuron migration IGI
IGI: Inferred from genetic interaction
11226314 MGI
acts upstream of or within positive regulation of protein kinase activity IGI
IGI: Inferred from genetic interaction
11517264 MGI
acts upstream of or within positive regulation of protein targeting to membrane IDA
IDA: Inferred from direct assay
18054859 MGI
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
20624590 MGI
involved in regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
17143272 MGI
involved in regulation of microtubule cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
20624590 MGI
acts upstream of or within serine phosphorylation of STAT protein IDA
IDA: Inferred from direct assay
15096606 MGI
acts upstream of or within superior olivary nucleus maturation IGI
IGI: Inferred from genetic interaction
11517264 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15123626 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15096606 MGI
part of protein kinase 5 complex IPI
IPI: Inferred from physical interaction
18325333 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclin-dependent kinase 5 activator 1

  • CDK5 activator 1

  • TPKII regulatory subunit

  • cyclin-dependent kinase 5 regulatory subunit 1

  • cyclin-dependent kinase 5, regulatory subunit (p35) 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02387 CDK5R1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20536 Cdk5r1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27045 Cdk5r1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk5r1 NCBI NCBI:8851