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CDK5R1 - cyclin dependent kinase 5 regulatory subunit 1 Gene

Also Known as p23; p25; p35; CDK5R; NCK5A; CDK5P35; p35nck5a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8851

About CDK5R1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:32,486,993-32,491,253 (from NCBI)

This gene has 3 transcripts (splice variants), 289 orthologues and 1 paralogue. Biased expression in brain (RPKM 36.6), lymph node (RPKM 6.6) and 5 other tissues.

Summary

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]

CDK5R1 Products (1)

mRNA	Protein	Name
NM_003885.3	NP_003876.1	cyclin-dependent kinase 5 activator 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cyclin-dependent protein serine/threonine kinase activator activity	IGI IGI: Inferred from genetic interaction	17517623	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8090221	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12832520	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	12832520	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20357208	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	12832520	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	12832520	GOA
involved in positive regulation of MHC class II biosynthetic process	IDA IDA: Inferred from direct assay	29020624	GOA
involved in positive regulation of signaling receptor activity	IDA IDA: Inferred from direct assay	29020624	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of cyclin-dependent protein kinase holoenzyme complex	IPI IPI: Inferred from physical interaction	16039528	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12832520	GOA
part of protein kinase 5 complex	IPI IPI: Inferred from physical interaction	15689152	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK5R1 Protein Structure

CDK5_activator

0
100
200
307 a.a.

Protein Preferred Names	Protein Names
cyclin-dependent kinase 5 activator 1	CDK5 activator 1

CDK5R1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDK5R1	Q15078	CAMTA2	Homo sapiens	O94983-5	Y2H Array	32814053
Intra	CDK5R1	Q15078	CAMTA2	Homo sapiens	O94983-5	Y2H Pooling	32814053
Intra	CDK5R1	Q15078	CAMTA2	Homo sapiens	O94983-5	Validated Y2H	32814053
Intra	CDK5R1	Q15078	TPX2	Homo sapiens	Q9ULW0	Y2H Array	32814053
Intra	CDK5R1	Q15078	TPX2	Homo sapiens	Q9ULW0	Validated Y2H	32814053
Intra	CDK5R1	Q15078	TPX2	Homo sapiens	Q9ULW0	Y2H Pooling	32814053
Intra	CDK5R1	Q15078	CDK5	Homo sapiens	Q00535	Anti Tag CoIP	28514442
Intra	CDK5R1	Q15078	CDK5	Homo sapiens	Q00535	X-Ray Diffraction	15689152
Intra	CDK5R1	Q15078	CDK5	Homo sapiens	Q00535	Anti Tag CoIP	23543736
Intra	CDK5R1	Q15078	CDK5	Homo sapiens	Q00535	Anti Tag CoIP	33961781
Intra	CDK5R1	Q15078	EPCAM	Homo sapiens	P16422	Y2H Array	32814053
Intra	CDK5R1	Q15078	EPCAM	Homo sapiens	P16422	Y2H Pooling	32814053
Intra	CDK5R1	Q15078	EPCAM	Homo sapiens	P16422	Validated Y2H	32814053
Intra	CDK5R1	Q15078	NEK6	Homo sapiens	Q9HC98-4	Validated Y2H	32814053
Intra	CDK5R1	Q15078	NEK6	Homo sapiens	Q9HC98-4	Y2H Array	32814053
Intra	CDK5R1	Q15078	NEK6	Homo sapiens	Q9HC98-4	Y2H Pooling	32814053
Intra	CDK5R1	Q15078	AATK	Homo sapiens	Q6ZMQ8-1	Anti Bait CoIP	14521924
Intra	CDK5R1	Q15078	AATK	Homo sapiens	Q6ZMQ8-2	Anti Bait CoIP	14521924
Intra	CDK5R1	Q15078	DNASE1L1	Homo sapiens	P49184	Validated Y2H	32814053
Intra	CDK5R1	Q15078	DNASE1L1	Homo sapiens	P49184	Y2H Array	32814053
Intra	CDK5R1	Q15078	DNASE1L1	Homo sapiens	P49184	Y2H Pooling	32814053
Intra	CDK5R1	Q15078	CRELD2	Homo sapiens	Q6UXH1-2	Y2H Array	32814053
Intra	CDK5R1	Q15078	CRELD2	Homo sapiens	Q6UXH1-2	Validated Y2H	32814053
Intra	CDK5R1	Q15078	CRELD2	Homo sapiens	Q6UXH1-2	Y2H Pooling	32814053
Intra	CDK5R1	Q15078	q9bq29_human	Homo sapiens	Q9BQ29	Y2H Pooling	32814053
Intra	CDK5R1	Q15078	q9bq29_human	Homo sapiens	Q9BQ29	Validated Y2H	32814053
Intra	CDK5R1	Q15078	q9bq29_human	Homo sapiens	Q9BQ29	Y2H Array	32814053
Intra	CDK5R1	Q15078	PRAM1	Homo sapiens	Q96QH2	Validated Y2H	32814053
Intra	CDK5R1	Q15078	PRAM1	Homo sapiens	Q96QH2	Y2H Array	32814053
Intra	CDK5R1	Q15078	PRAM1	Homo sapiens	Q96QH2	Y2H Pooling	32814053
Intra	CDK5R1	Q15078	MYNN	Homo sapiens	Q9NPC7	Y2H Pooling	32814053
Intra	CDK5R1	Q15078	MYNN	Homo sapiens	Q9NPC7	Validated Y2H	32814053
Intra	CDK5R1	Q15078	MYNN	Homo sapiens	Q9NPC7	Y2H Array	32814053
Intra	CDK5R1	Q15078	SLC25A11	Homo sapiens	Q02978	Validated Y2H	32814053
Intra	CDK5R1	Q15078	SLC25A11	Homo sapiens	Q02978	Y2H Array	32814053
Intra	CDK5R1	Q15078	SLC25A11	Homo sapiens	Q02978	Y2H Pooling	32814053
Intra	CDK5R1	Q15078	RAB3C	Homo sapiens	Q96E17	Validated Y2H	32814053
Intra	CDK5R1	Q15078	RAB3C	Homo sapiens	Q96E17	Y2H Pooling	32814053
Intra	CDK5R1	Q15078	RAB3C	Homo sapiens	Q96E17	Y2H Array	32814053
Intra	CDK5R1	Q15078	PIAS4	Homo sapiens	Q8N2W9	Y2H Pooling	32814053
Intra	CDK5R1	Q15078	PIAS4	Homo sapiens	Q8N2W9	Validated Y2H	32814053
Intra	CDK5R1	Q15078	PIAS4	Homo sapiens	Q8N2W9	Y2H Array	32814053
Intra	CDK5R1	Q15078	MAGEA2	Homo sapiens	P43356	Y2H Pooling	32814053
Intra	CDK5R1	Q15078	MAGEA2	Homo sapiens	P43356	Validated Y2H	32814053
Intra	CDK5R1	Q15078	MAGEA2	Homo sapiens	P43356	Y2H Array	32814053
Intra	CDK5R1	Q15078	THAP7	Homo sapiens	Q9BT49	Validated Y2H	32814053
Intra	CDK5R1	Q15078	THAP7	Homo sapiens	Q9BT49	Y2H Pooling	32814053
Intra	CDK5R1	Q15078	THAP7	Homo sapiens	Q9BT49	Y2H Array	32814053
Intra	CDK5R1	Q15078	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	CDK5R1	Q15078	MFI	Homo sapiens	Q8NCR3	Validated Y2H	32814053
Intra	CDK5R1	Q15078	MFI	Homo sapiens	Q8NCR3	Y2H Pooling	32814053
Intra	CDK5R1	Q15078	MFI	Homo sapiens	Q8NCR3	Y2H Array	32814053
Intra	CDK5R1	Q15078	KLRC1	Homo sapiens	P26715	Validated Y2H	32814053
Intra	CDK5R1	Q15078	KLRC1	Homo sapiens	P26715	Y2H Array	32814053
Intra	CDK5R1	Q15078	KLRC1	Homo sapiens	P26715	Y2H Pooling	32814053
Intra	CDK5R1	Q15078	MYBPHL	Homo sapiens	A2RUH7	Y2H Array	32814053
Intra	CDK5R1	Q15078	MYBPHL	Homo sapiens	A2RUH7	Y2H Pooling	32814053
Intra	CDK5R1	Q15078	MYBPHL	Homo sapiens	A2RUH7	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Alzheimer Disease 12	Ad12 Alzheimer'S Disease 12 Alzheimer Disease, Familial, 12 Alzheimer Disease Familial 12
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02387	CDK5R1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20536	Cdk5r1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27045	Cdk5r1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CDK5R1	VGNC	VGNC:70981
Canis familiaris	CDK5R1	VGNC	VGNC:39055
Mus musculus	CDK5R1	MGD	MGI:101764
Bos taurus	CDK5R1	VGNC	VGNC:27128
Rattus norvegicus	CDK5R1	RGD	RGD:629472
Felis catus	CDK5R1	VGNC	VGNC:60701
Others	CDK5R1	NCBI