Cebpb - CCAAT/enhancer binding protein (C/EBP), beta Gene

Also Known as LAP; LIP; CRP2; NF-M; Nfil6; NF-IL6; IL-6DBP; C/EBPbeta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12608

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding activity; and enzyme binding activity. Contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including liver development; regulation of leukocyte differentiation; and response to bacterium. Acts upstream of or within several processes, including mammary gland epithelium development; positive regulation of osteoblast differentiation; and regulation of gene expression. Located in chromosome; cytoplasm; and nuclear matrix. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including adrenal gland; alimentary system; extraembryonic component; genitourinary system; and integumental system. Used to study cleidocranial dysplasia and viral infectious disease. Orthologous to human CEBPB (CCAAT enhancer binding protein beta). [provided by Alliance of Genome Resources, Apr 2022]

Cebpb Products (3)

mRNA Protein Name
NM_001287738.1 NP_001274667.1 CCAAT/enhancer-binding protein beta isoform b
NM_001287739.1 NP_001274668.1 CCAAT/enhancer-binding protein beta isoform c
NM_009883.4 NP_034013.1 CCAAT/enhancer-binding protein beta isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
10510303 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10588870 MGI
contributes to DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
27812542 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
19641492 MGI
contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
27812542 MGI
enables RNA polymerase II core promoter sequence-specific DNA binding IDA
IDA: Inferred from direct assay
25472717 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
25921091 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
21122806 MGI
enables histone acetyltransferase binding IPI
IPI: Inferred from physical interaction
17301242 MGI
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
18486321 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
12177065 MGI
enables kinase binding IPI
IPI: Inferred from physical interaction
10635333 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11684016 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10588870 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
24216764 MGI
enables ubiquitin-like protein ligase binding IPI
IPI: Inferred from physical interaction
24061474 MGI
Biological Process GO Annotation Evidence References Source
involved in T-helper 1 cell activation IMP
IMP: Inferred from mutant phenotype
17911624 MGI
involved in brown fat cell differentiation IMP
IMP: Inferred from mutant phenotype
19641492 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
involved in defense response to bacterium IMP
IMP: Inferred from mutant phenotype
17911624 MGI
acts upstream of or within embryonic placenta development IGI
IGI: Inferred from genetic interaction
15509779 MGI
acts upstream of or within fat cell differentiation IDA
IDA: Inferred from direct assay
15509789 MGI
acts upstream of or within fat cell differentiation IGI
IGI: Inferred from genetic interaction
17888405 MGI
involved in granuloma formation IMP
IMP: Inferred from mutant phenotype
17911624 MGI
involved in hepatocyte proliferation IDA
IDA: Inferred from direct assay
10635333 MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
9531536 MGI
involved in liver regeneration IMP
IMP: Inferred from mutant phenotype
9727068 MGI
acts upstream of or within mammary gland epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
10707954 MGI
acts upstream of or within mammary gland epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
10683373 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15175325 MGI
involved in negative regulation of T cell proliferation IDA
IDA: Inferred from direct assay
16585579 MGI
acts upstream of or within negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
11684016 MGI
acts upstream of or within neuron differentiation IDA
IDA: Inferred from direct assay
11733516 MGI
involved in ovarian follicle development IMP
IMP: Inferred from mutant phenotype
9303532 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15870285 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
15762841 MGI
involved in positive regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
19324970 MGI
involved in positive regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
26526992 MGI
involved in positive regulation of interleukin-4 production IDA
IDA: Inferred from direct assay
16585579 MGI
acts upstream of or within positive regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
15175325 MGI
involved in positive regulation of transcription by RNA polymerase II EXP
EXP: Inferred from Experiment
11792321 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10859308 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18486321 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
22078933 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
25472717 MGI
involved in regulation of dendritic cell differentiation IGI
IGI: Inferred from genetic interaction
26526992 MGI
acts upstream of or within regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
11976687 MGI
involved in regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
19440205 MGI
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19324970 MGI
involved in response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
17724128 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10859308 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
22078933 MGI
Cellular Component GO Annotation Evidence References Source
part of C/EBP complex IPI
IPI: Inferred from physical interaction
17264204 MGI
part of RNA polymerase II transcription regulator complex EXP
EXP: Inferred from Experiment
11792321 MGI
part of RNA polymerase II transcription regulator complex IDA
IDA: Inferred from direct assay
27812542 MGI
located in chromatin IDA
IDA: Inferred from direct assay
15187136 MGI
located in condensed chromosome, centromeric region IDA
IDA: Inferred from direct assay
21122806 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11684016 MGI
located in nuclear matrix IDA
IDA: Inferred from direct assay
21122806 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10588870 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CCAAT/enhancer-binding protein beta

  • AGP/EBP

  • C/EBP BETA

  • interleukin-6-dependent-binding protein

  • liver-enriched transcriptional activator

  • nuclear protein Il6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02446 CEBPB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23873 Cebpb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17419 Cebpb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cebpb NCBI NCBI:1051