Chrm1 - cholinergic receptor, muscarinic 1, CNS Gene

Also Known as M1; M1R; Chrm-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12669

Summary

Enables neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within regulation of locomotion. Located in cholinergic synapse. Is active in Schaffer collateral - CA1 synapse. Is integral component of postsynaptic membrane. Is expressed in central nervous system; retina; and urinary system. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; asthma; and myasthenia gravis. Orthologous to human CHRM1 (cholinergic receptor muscarinic 1). [provided by Alliance of Genome Resources, Apr 2022]

Chrm1 Products (2)

mRNA Protein Name
NM_001112697.1 NP_001106167.1 muscarinic acetylcholine receptor M1
NM_007698.3 NP_031724.2 muscarinic acetylcholine receptor M1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in postsynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
26472558 MGI
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
26472558 MGI
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
26472558 MGI
acts upstream of or within regulation of locomotion IMP
IMP: Inferred from mutant phenotype
11752469 MGI
involved in regulation of postsynaptic membrane potential EXP
EXP: Inferred from Experiment
26472558 MGI
involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
26472558 MGI
involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
26472558 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse EXP
EXP: Inferred from Experiment
26472558 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
26472558 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
26472558 MGI
is active in cholinergic synapse IDA
IDA: Inferred from direct assay
20335477 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
20335477 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

muscarinic acetylcholine receptor M1

  • AChR M1

  • m1 muscarinic acetylcholine receptor protein

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0298 Clemastine 99.26% Yes

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0735 Phellodendrine chloride 99.68% Unkown
HY-N0427 Phellodendrine 99.60% Unkown
HY-RS02660 CHRM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18169 Chrm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24643 Chrm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrm1 NCBI NCBI:1128