CNR1 - cannabinoid receptor 1 Gene
Also Known as CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5
Species: Homo sapiens
About CNR1
This gene has 7 transcripts (splice variants), 206 orthologues and 18 paralogues. Biased expression in brain (RPKM 6.2), fat (RPKM 2.7) and 12 other tissues.
Summary
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit Adenylate Cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
CNR1 Products (17)
| mRNA | Protein | Name |
|---|---|---|
| XM_047418173.1 | XP_047274129.1 | cannabinoid receptor 1 isoform X1 |
| NM_001160226.3 | NP_001153698.1 | cannabinoid receptor 1 isoform a |
| NM_001365874.3 | NP_001352803.1 | cannabinoid receptor 1 isoform a |
| NM_001365872.2 | NP_001352801.1 | cannabinoid receptor 1 isoform a |
| XM_047418171.1 | XP_047274127.1 | cannabinoid receptor 1 isoform X1 |
| NM_016083.6 | NP_057167.2 | cannabinoid receptor 1 isoform a |
| XM_011535425.3 | XP_011533727.1 | cannabinoid receptor 1 isoform X1 |
| NM_001160258.3 | NP_001153730.1 | cannabinoid receptor 1 isoform a |
| XM_047418172.1 | XP_047274128.1 | cannabinoid receptor 1 isoform X1 |
| NM_001160260.1 | ||
| NM_001365869.2 | NP_001352798.1 | cannabinoid receptor 1 isoform a |
| NM_001370545.1 | NP_001357474.1 | cannabinoid receptor 1 isoform a |
| NM_001370546.1 | NP_001357475.1 | cannabinoid receptor 1 isoform a |
| NM_001370547.1 | NP_001357476.1 | cannabinoid receptor 1 isoform a |
| NM_033181.4 | NP_149421.2 | cannabinoid receptor 1 isoform b |
| NM_001365870.2 | NP_001352799.1 | cannabinoid receptor 1 isoform a |
| NM_001160259.3 | NP_001153731.1 | cannabinoid receptor 1 isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables cannabinoid receptor activity |
IDA
IDA: Inferred from direct assay
|
18761332 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
20590567 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
17356572 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
IDA
IDA: Inferred from direct assay
|
18761332 | GOA |
| involved in cannabinoid signaling pathway |
IDA
IDA: Inferred from direct assay
|
17895407 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
17895407 | GOA |
CNR1 Protein Structure
7tm_1: 7 transmembrane receptor (rhodopsin family) (133 - 397)
- 0
- 100
- 200
- 300
- 400
- 472 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
cannabinoid receptor 1 |
|
CNR1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CNR1 | P21554 | ADORA2A | Homo sapiens | P29274 | 17356572 | |
|
Intra
|
CNR1 | P21554 | ADORA2A | Homo sapiens | P29274 | 28102227 | |
|
Intra
|
CNR1 | P21554 | ADORA2A | Homo sapiens | P29274 | 17356572 | |
|
Intra
|
CNR1 | P21554 | DRD2 | Homo sapiens | P14416 | 28734930 | |
|
Intra
|
CNR1 | P21554 | CNR1 | Homo sapiens | P21554 | 20590567 | |
|
Intra
|
CNR1 | P21554 | CNR1 | Homo sapiens | P21554 | 28734930 | |
|
Intra
|
CNR1 | P21554 | CNR1 | Homo sapiens | P21554 | 28734930 | |
|
Intra
|
CNR1 | P21554 | CNR1 | Homo sapiens | P21554 | 28734930 | |
|
Intra
|
CNR1 | P21554 | DRD2 | Homo sapiens | P14416 | 28734930 |
Recombinant CNR1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P700408 | CNR1 Protein-VLP, Human (HEK293, His) | P21554 (M1-L472) | Purity analysis by SDS-PAGE is not available for VLP proteins. |
CNR1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81627 | Cannabinoid Receptor I Antibody | WB, IHC-P, IHC-F, ICC/IF, ELISA | Human, Rat |
| HY-P82605 | Phospho-Cannabinoid Receptor I (Ser316) Antibody (YA2350) | WB | Human |
| HY-P82605A | Phospho-Cannabinoid Receptor I (Ser316) Antibody (YA2350)(PBS only) | WB | Human |
| HY-P89397 | Cannabinoid Receptor I Antibody (YA8850) | WB, IHC-P | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Huntington Disease |
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| Specific Developmental Disorder |
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| Parkinson Disease, Late-Onset |
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| Fragile X Syndrome |
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| Anorexia Nervosa |
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| Constipation |
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| Alzheimer Disease, Familial, 1 |
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| Cerebral Angioma |
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| Epilepsy |
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| Osteoporosis |
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| Anxiety |
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| Bipolar Disorder |
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| Dravet Syndrome |
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| Nervous System Disease |
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| Mood Disorder |
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| Developmental And Epileptic Encephalopathy |
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| Lipid Metabolism Disorder |
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| Tobacco Addiction |
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| Asperger Syndrome |
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| Diabetes Mellitus |
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| Amyotrophic Lateral Sclerosis 1 |
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| Substance Dependence |
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| Body Mass Index Quantitative Trait Locus 11 |
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| Cannabis Dependence |
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| Fetal Alcohol Spectrum Disorder |
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| Type 2 Diabetes Mellitus |
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| Sveinsson Chorioretinal Atrophy |
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| Eating Disorder |
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| Fetal Alcohol Syndrome |
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| Myocardial Infarction |
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| Alcohol Dependence |
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| Multiple Sclerosis |
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| Hallucinogen Dependence |
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| Gilles De La Tourette Syndrome |
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| Schizophrenia 15 |
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| Psychotic Disorder |
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| Bulimia Nervosa |
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| Lennox-Gastaut Syndrome |
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| Drug Dependence |
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| Cannabis Abuse |
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| Dystonia |
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| Migraine With Or Without Aura 1 |
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| Chronic Pain |
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| Schizophrenia |
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| Aids Wasting Syndrome |
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| Substance Abuse |
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| Uvulitis |
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| Post-Traumatic Stress Disorder |
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| Retinitis Pigmentosa 30 |
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| Intraocular Pressure Quantitative Trait Locus |
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| Central Nervous System Disease |
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| Pain Agnosia |
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| Heroin Dependence |
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| Withdrawal Disorder |
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| Agnosia |
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| Attention Deficit-Hyperactivity Disorder |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | CNR1 | VGNC | VGNC:39426 |
| Mus musculus | CNR1 | MGD | MGI:104615 |
| Macaca mulatta | CNR1 | VGNC | VGNC:71280 |
| Bos taurus | CNR1 | VGNC | VGNC:27529 |
| Rattus norvegicus | CNR1 | RGD | RGD:2369 |
| Others | CNR1 | NCBI |