Clgn - calmegin Gene

Also Known as Cln; A2/6; 4930459O04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12745

Summary

This gene belongs to the calreticulin family, which includes calreticulin, calnexin, and calmegin, and encodes a calcium-binding molecular chaperone specifically expressed in pachytene stage male germ cells. It is required for the proper folding of newly synthesized membrane proteins in the endoplasmic reticulum including those critical for sperm migration from the uterus into the oviduct and sperm adhesion to and penetration of the zona pellucida. This gene plays a key role in spermatogenesis and male infertility. Alternative splice variants exist for this gene. [provided by RefSeq, Jul 2016]

Clgn Products (3)

mRNA Protein Name
NM_001329627.1 NP_001316556.1 calmegin isoform 1 precursor
NM_001329680.1 NP_001316609.1 calmegin isoform 2
NM_009904.4 NP_034034.2 calmegin isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22357757 MGI
enables protein folding chaperone IMP
IMP: Inferred from mutant phenotype
22357757 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within binding of sperm to zona pellucida IMP
IMP: Inferred from mutant phenotype
9177349 MGI
acts upstream of or within protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
11784061 MGI
acts upstream of or within single fertilization IGI
IGI: Inferred from genetic interaction
22621904 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calmegin

  • MEG 1 antigen

  • calnexin-T

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02802 CLGN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08516 MMP1 Human Pre-designed siRNA Set A / Unkown
HY-RS08517 Mmp1 Rat Pre-designed siRNA Set A / Unkown
HY-RS18919 Clgn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25409 Clgn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clgn NCBI NCBI:1047