Ackr3 - atypical chemokine receptor 3 Gene

Also Known as Rdc1; Cxcr7; RDC-1; CXC-R7; CXCR-7; Cmkor1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12778

About Ackr3

Chromosome 1: 90,131,702-90,144,473 forward strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 252 orthologues, 25 paralogues and is associated with 49 phenotypes. Broad expression in adrenal adult (RPKM 169.3), heart adult (RPKM 116.2) and 2 other tissues.

Summary

Predicted to enable chemokine binding activity; Chemokine Receptor activity; and scavenger receptor activity. Acts upstream of or within negative regulation of cell population proliferation and positive regulation of ERK1 and ERK2 cascade. Predicted to be located in several cellular components, including cell surface; clathrin-coated pit; and endosome. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; heart; and hemolymphoid system. Orthologous to human ACKR3 (atypical Chemokine Receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Ackr3 Products (2)

mRNA Protein Name
NM_007722.4 NP_031748.2 atypical chemokine receptor 3
NM_001271607.1 NP_001258536.1 atypical chemokine receptor 3

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
22956548 MGI
involved in oculomotor nerve development IMP
IMP: Inferred from mutant phenotype
31211835 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
22956548 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ackr3 Protein Structure

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (44 - 325)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (45 - 71)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (78 - 102)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (116 - 146)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (159 - 180)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (208 - 235)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (244 - 274)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (293 - 318)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
Protein Preferred Names Protein Names

atypical chemokine receptor 3

  • C-X-C chemokine receptor type 7

  • G-protein coupled receptor RDC1 homolog

  • chemokine (C-X-C motif) receptor 7

  • chemokine orphan receptor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10333A LIH383 TFA Agonist 99.83% Unkown
HY-123813 CCX-777 Agonist 98.47% Unkown
HY-123813A CCX-777 formic Agonist 98.01% Unkown
HY-RS00162 ACKR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-159582 ACKR3 agonist 1 Agonist / Unkown
HY-161414 trans-VUF25471 Agonist / Unkown
HY-179035 TBS6b Degrader / Unkown
HY-182533 LN5972 Agonist / Unkown
HY-D2201 Fluorescent ACKR3 antagonist 1 / Unkown
HY-P10333 LIH383 Agonist / Unkown
HY-RS00163 Ackr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00164 Ackr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174787 Human ACKR3 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ackr3 NCBI NCBI:57007