Crk - v-crk avian sarcoma virus CT10 oncogene homolog Gene

Also Known as p38; Crk3; Crko; Crk-I; c-Crk; Crk-II; CrkIII; Crk-III

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12928

Summary

This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In mouse this protein is essential for embryonic development. Alternatively spliced transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Mar 2013]

Crk Products (3)

mRNA Protein Name
NM_001277219.1 NP_001264148.1 adapter molecule crk isoform 1
NM_001277221.1 NP_001264150.1 adapter molecule crk isoform 3
NM_133656.5 NP_598417.2 adapter molecule crk isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ephrin receptor binding IPI
IPI: Inferred from physical interaction
11870224 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9480911 MGI
enables protein phosphorylated amino acid binding IDA
IDA: Inferred from direct assay
9729467 MGI
enables signaling adaptor activity IDA
IDA: Inferred from direct assay
21041412 MGI
enables signaling receptor complex adaptor activity IPI
IPI: Inferred from physical interaction
9447983 MGI
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
9447983 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within activation of GTPase activity IGI
IGI: Inferred from genetic interaction
25621495 MGI
acts upstream of or within cell chemotaxis IGI
IGI: Inferred from genetic interaction
25621495 MGI
involved in cell population proliferation IGI
IGI: Inferred from genetic interaction
15781341 MGI
acts upstream of or within cerebellar neuron development IGI
IGI: Inferred from genetic interaction
19074029 MGI
acts upstream of or within cerebral cortex development IGI
IGI: Inferred from genetic interaction
19074029 MGI
acts upstream of or within dendrite development IGI
IGI: Inferred from genetic interaction
19074029 MGI
involved in enzyme-linked receptor protein signaling pathway IDA
IDA: Inferred from direct assay
18848351 MGI
involved in enzyme-linked receptor protein signaling pathway IGI
IGI: Inferred from genetic interaction
8653787 MGI
involved in enzyme-linked receptor protein signaling pathway IMP
IMP: Inferred from mutant phenotype
14622576 MGI
acts upstream of or within establishment of cell polarity IGI
IGI: Inferred from genetic interaction
25621495 MGI
acts upstream of or within helper T cell diapedesis IGI
IGI: Inferred from genetic interaction
25621495 MGI
acts upstream of or within hippocampus development IGI
IGI: Inferred from genetic interaction
19074029 MGI
acts upstream of or within lipid metabolic process IGI
IGI: Inferred from genetic interaction
29581031 MGI
acts upstream of or within neuron migration IGI
IGI: Inferred from genetic interaction
19074029 MGI
involved in positive regulation of Rac protein signal transduction IMP
IMP: Inferred from mutant phenotype
21041412 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IDA
IDA: Inferred from direct assay
18848351 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IGI
IGI: Inferred from genetic interaction
8653787 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IMP
IMP: Inferred from mutant phenotype
14622576 MGI
involved in postsynaptic specialization assembly IDA
IDA: Inferred from direct assay
21041412 MGI
involved in postsynaptic specialization assembly IMP
IMP: Inferred from mutant phenotype
21041412 MGI
acts upstream of or within reelin-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
18477607 MGI
acts upstream of or within regulation of T cell migration IGI
IGI: Inferred from genetic interaction
25621495 MGI
acts upstream of or within regulation of actin cytoskeleton organization IGI
IGI: Inferred from genetic interaction
20980600 MGI
acts upstream of or within regulation of cell adhesion mediated by integrin IGI
IGI: Inferred from genetic interaction
25621495 MGI
acts upstream of or within regulation of dendrite development IGI
IGI: Inferred from genetic interaction
18477607 MGI
acts upstream of or within regulation of leukocyte migration IGI
IGI: Inferred from genetic interaction
25621495 MGI
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
11864995 MGI
located in membrane IMP
IMP: Inferred from mutant phenotype
22801373 MGI
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
21041412 MGI
is active in neuromuscular junction IMP
IMP: Inferred from mutant phenotype
21041412 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adapter molecule crk

  • CT-10 related kinase 3

  • avian sarcoma virus CT10 (v-crk) oncogene homolog

  • proto-oncogene c-crk

  • v-crk sarcoma virus CT10 oncogene-like protein

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112622 GSK3186899 Inhibitor 98.96% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16222 Crk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-112346 RGB-286147 98.60% Unkown
HY-143322 CRK12-IN-2 Inhibitor / Unkown
HY-145812 CRK12-IN-1 Inhibitor / Unkown
HY-RS03184 CRK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23979 Crk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Crk NCBI NCBI:1398