Ctbp2 - C-terminal binding protein 2 Gene
Also Known as Ribeye; Gtrgeo6; D7Ertd45e
Species: Mus musculus
Summary
Enables several functions, including retinoic acid receptor binding activity; transcription coactivator activity; and transcription corepressor activity. A structural constituent of presynaptic active zone. Involved in negative regulation of transcription, DNA-templated; synaptic vesicle docking; and white fat cell differentiation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of chromatin binding activity; and positive regulation of retinoic acid receptor signaling pathway. Located in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and photoreceptor ribbon synapse. Part of transcription repressor complex. Is active in presynaptic active zone cytoplasmic component and presynaptic cytosol. Is expressed in several structures, including alimentary system; limb; lung; nervous system; and retina layer. Orthologous to human CTBP2 (C-terminal binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Ctbp2 Products (19)
| mRNA | Protein | Name |
|---|---|---|
| NM_001170744.2 | NP_001164215.1 | C-terminal-binding protein 2 isoform 1 |
| NM_001347623.2 | NP_001334552.1 | C-terminal-binding protein 2 isoform 3 |
| NM_001412294.1 | NP_001399223.1 | C-terminal-binding protein 2 isoform 4 |
| NM_001412295.1 | NP_001399224.1 | C-terminal-binding protein 2 isoform 2 |
| NM_001412296.1 | NP_001399225.1 | C-terminal-binding protein 2 isoform 2 |
| NM_001412297.1 | NP_001399226.1 | C-terminal-binding protein 2 isoform 2 |
| NM_001412298.1 | NP_001399227.1 | C-terminal-binding protein 2 isoform 2 |
| NM_001412299.1 | NP_001399228.1 | C-terminal-binding protein 2 isoform 2 |
| NM_001412300.1 | NP_001399229.1 | C-terminal-binding protein 2 isoform 2 |
| NM_001412301.1 | NP_001399230.1 | C-terminal-binding protein 2 isoform 2 |
| NM_001412302.1 | NP_001399231.1 | C-terminal-binding protein 2 isoform 2 |
| NM_001412303.1 | NP_001399232.1 | C-terminal-binding protein 2 isoform 3 |
| NM_001412304.1 | NP_001399233.1 | C-terminal-binding protein 2 isoform 3 |
| NM_001412305.1 | NP_001399234.1 | C-terminal-binding protein 2 isoform 3 |
| NM_001412306.1 | NP_001399235.1 | C-terminal-binding protein 2 isoform 3 |
| NM_001412307.1 | NP_001399236.1 | C-terminal-binding protein 2 isoform 3 |
| NM_001412308.1 | NP_001399237.1 | C-terminal-binding protein 2 isoform 3 |
| NM_001412309.1 | NP_001399238.1 | C-terminal-binding protein 2 isoform 3 |
| NM_009980.5 | NP_034110.1 | C-terminal-binding protein 2 isoform 2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables chromatin binding |
IDA
IDA: Inferred from direct assay
|
23775127 | MGI |
| enables nuclear retinoic acid receptor binding |
IPI
IPI: Inferred from physical interaction
|
23775127 | MGI |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
11328817 | MGI |
| enables structural constituent of presynaptic active zone |
IDA
IDA: Inferred from direct assay
|
26929012 | MGI |
| enables structural constituent of presynaptic active zone |
IMP
IMP: Inferred from mutant phenotype
|
26929012 | MGI |
| enables transcription coactivator activity |
IGI
IGI: Inferred from genetic interaction
|
23775127 | MGI |
| enables transcription coregulator binding |
IPI
IPI: Inferred from physical interaction
|
10438528 | MGI |
| enables transcription corepressor activity |
IDA
IDA: Inferred from direct assay
|
10567582 | MGI |
| enables transcription corepressor activity |
IPI
IPI: Inferred from physical interaction
|
12444977 | MGI |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| is active in GABA-ergic synapse |
IDA
IDA: Inferred from direct assay
|
22745816 | MGI |
| is active in glutamatergic synapse |
IDA
IDA: Inferred from direct assay
|
15728193 | MGI |
| is active in glutamatergic synapse |
IMP
IMP: Inferred from mutant phenotype
|
26929012 | MGI |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
16702210 | MGI |
| is active in photoreceptor ribbon synapse |
IDA
IDA: Inferred from direct assay
|
15728193 | MGI |
| is active in photoreceptor ribbon synapse |
IMP
IMP: Inferred from mutant phenotype
|
26929012 | MGI |
| is active in presynaptic active zone cytoplasmic component |
IDA
IDA: Inferred from direct assay
|
15728193 | MGI |
| is active in presynaptic cytosol |
IDA
IDA: Inferred from direct assay
|
22745816 | MGI |
| located in ribbon synapse |
IDA
IDA: Inferred from direct assay
|
19932743 | MGI |
| located in synapse |
IDA
IDA: Inferred from direct assay
|
20368623 | MGI |
| part of transcription repressor complex |
IDA
IDA: Inferred from direct assay
|
18483224 | MGI |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
C-terminal-binding protein 2 |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-135046 | MTOB sodium | Inhibitor | 97.02% | Unkown |
| HY-RS03284 | CTBP2 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS20897 | Ctbp2 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS27414 | Ctbp2 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Compound Screening Libraries
Virtual Screening
Customize Your Library
Drug Screening Service