Ctsk - cathepsin K Gene

Also Known as catK; Ms10q; MMS10-Q

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13038

About Ctsk

Chromosome 3: 95,406,567-95,416,673 forward strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 240 orthologues, 24 paralogues and is associated with 55 phenotypes. Biased expression in bladder adult (RPKM 27.4), limb E14.5 (RPKM 13.7) and 12 other tissues.

Summary

This gene encodes a member of the Cathepsin family of cysteine proteases that is highly expressed in osteoclasts and is involved in the degradation of Collagen and Other matrix proteins in bone. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme. Mice lacking the encoded protein exhibit phenotypic features of pycnodysostosis such as increased bone density and bone deformity, which become progressively more pronounced with age. [provided by RefSeq, Jan 2016]

Ctsk Products (1)

mRNA Protein Name
NM_007802.4 NP_031828.2 cathepsin K preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within bone resorption IMP
IMP: Inferred from mutant phenotype
19834056 MGI
acts upstream of or within collagen catabolic process IMP
IMP: Inferred from mutant phenotype
19834056 MGI
acts upstream of or within negative regulation of cartilage development IMP
IMP: Inferred from mutant phenotype
19834056 MGI
involved in proteolysis involved in protein catabolic process IMP
IMP: Inferred from mutant phenotype
12782676 MGI
involved in thyroid hormone generation IMP
IMP: Inferred from mutant phenotype
12782676 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
12782676 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
12782676 MGI
located in lysosome IDA
IDA: Inferred from direct assay
12782676 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctsk Protein Structure

Inhibitor_I29

Inhibitor_I29: smart00848 (25 - 84)

Peptidase_C1

Peptidase_C1: pfam00112 (114 - 326)

  • 0
  • 100
  • 200
  • 300
  • 329 a.a.
Protein Preferred Names Protein Names

cathepsin K

  • Cat K

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117200 Necrostatin-7 Inhibitor 99.64% Unkown
HY-143714 Cathepsin K inhibitor 2 Inhibitor / Unkown
HY-155960 SH491 Inhibitor / Unkown
HY-182818 SH494 / Unkown
HY-RS03337 CTSK Human Pre-designed siRNA Set A / Unkown
HY-RS03338 Ctsk Mouse Pre-designed siRNA Set A / Unkown
HY-RS03339 Ctsk Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctsk NCBI NCBI:1513