Ddx5 - DEAD box helicase 5 Gene

Also Known as p68; Hlr1; G17P1; HUMP68; 2600009A06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13207

Summary

Enables RNA binding activity; promoter-specific chromatin binding activity; and transcription coregulator activity. Involved in several processes, including RNA metabolic process; regulation of alternative mRNA splicing, via spliceosome; and regulation of osteoblast differentiation. Acts upstream of or within circadian rhythm; positive regulation of transcription, DNA-templated; and protein import into nucleus. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human DDX5 (DEAD-box helicase 5). [provided by Alliance of Genome Resources, Apr 2022]

Ddx5 Products (3)

mRNA Protein Name
NM_001355676.1 NP_001342605.1 probable ATP-dependent RNA helicase DDX5
NM_001355677.1 NP_001342606.1 probable ATP-dependent RNA helicase DDX5
NM_007840.3 NP_031866.2 probable ATP-dependent RNA helicase DDX5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
22665494 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
24910439 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11279182 MGI
enables transcription coregulator activity IDA
IDA: Inferred from direct assay
15464984 MGI
Biological Process GO Annotation Evidence References Source
involved in alternative mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
24910439 MGI
acts upstream of or within circadian rhythm IMP
IMP: Inferred from mutant phenotype
22767893 MGI
involved in miRNA transcription IMP
IMP: Inferred from mutant phenotype
24910439 MGI
involved in myoblast differentiation IMP
IMP: Inferred from mutant phenotype
24910439 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15464984 MGI
acts upstream of or within protein import into nucleus IGI
IGI: Inferred from genetic interaction
22665494 MGI
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
23022728 MGI
involved in regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
17960593 MGI
involved in regulation of skeletal muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
17011493 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

probable ATP-dependent RNA helicase DDX5

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 5

  • DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 5

  • DEAD box RNA helicase DEAD1

  • DEAD box protein 5

  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5

  • RNA helicase p68

  • mDEAD1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-168739 Topoisomerase I inhibitor 17 / Phase 2
HY-12486 FL118 99.22% Phase 1

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-178226 PBX-7016 Inhibitor / Unkown
HY-160438B PBX-7011 TFA Inhibitor 98.60% Unkown
HY-160438A PBX-7011 mesylate Inhibitor / Unkown
HY-160438 PBX-7011 Inhibitor / Unkown
HY-181018 Topo I/DDX5-IN-1 / Unkown
HY-RS03655 DDX5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16886 Ddx5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23328 Ddx5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ddx5 NCBI NCBI:1655