Dr1 - down-regulator of transcription 1 Gene

Also Known as NC2; Dr1l; NC2beta; 1700121L09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13486

Summary

Predicted to enable RNA polymerase II general transcription initiation factor activity; TBP-class protein binding activity; and core promoter sequence-specific DNA binding activity. Predicted to be involved in several processes, including RNA polymerase II preinitiation complex assembly; histone H3 acetylation; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of ATAC complex. Is expressed in central nervous system; early conceptus; genitourinary system; limb mesenchyme; and neural retina. Orthologous to human DR1 (down-regulator of transcription 1). [provided by Alliance of Genome Resources, Apr 2022]

Dr1 Products (1)

mRNA Protein Name
NM_026106.4 NP_080382.2 protein Dr1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19103755 MGI
Biological Process GO Annotation Evidence References Source
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
19103755 MGI
involved in regulation of cell division IDA
IDA: Inferred from direct assay
20562830 MGI
involved in regulation of embryonic development IDA
IDA: Inferred from direct assay
19103755 MGI
Cellular Component GO Annotation Evidence References Source
part of ATAC complex IDA
IDA: Inferred from direct assay
19936620 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19103755 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Dr1

  • NC2-beta

  • TATA-binding protein-associated phosphoprotein

  • negative cofactor 2-beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150069 UBX1325 99.16% Unkown
HY-139170 CAY10746 Inhibitor 98.61% Unkown
HY-157269 J10-1 99.92% Unkown
HY-RS03986 DR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17102 Dr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23546 Dr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dr1 NCBI NCBI:1810