E2f3 - E2F transcription factor 3 Gene

Also Known as E2F3b; E2f3a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13557

Summary

Enables DNA binding activity and DNA-binding transcription factor activity. Involved in negative regulation of fat cell proliferation. Acts upstream of or within positive regulation of cell population proliferation and positive regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human E2F3 (E2F transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

E2f3 Products (3)

mRNA Protein Name
NM_001289920.1 NP_001276849.1 transcription factor E2F3 isoform E2f3b
NM_001359994.1 NP_001346923.1 transcription factor E2F3 isoform 3
NM_010093.3 NP_034223.1 transcription factor E2F3 isoform E2f3a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11980909 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11980909 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11980909 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of fat cell proliferation IMP
IMP: Inferred from mutant phenotype
20176812 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12893818 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12893818 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11980909 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor E2F3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-170820 XYD049 Inhibitor 99.46% Unkown
HY-RS04112 E2F3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19322 E2f3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25813 E2f3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens E2f3 NCBI NCBI:1871