CPA1 - carboxypeptidase A1 Gene

Also Known as CPA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1357

About CPA1

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,380,494-130,388,108 (from NCBI)

This gene has 9 transcripts (splice variants), 264 orthologues, 8 paralogues and is associated with 1 phenotype. Restricted expression toward pancreas (RPKM 26661.6).

Summary

This gene encodes a member of the Carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic Amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic Cancer. [provided by RefSeq, Jan 2015]

CPA1 Products (1)

mRNA Protein Name
NM_001868.4 NP_001859.1 carboxypeptidase A1 preproprotein

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables metallocarboxypeptidase activity IDA
IDA: Inferred from direct assay
20385563 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19179285 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
2920728 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPA1 Protein Structure

Propep_M14

Propep_M14: Carboxypeptidase activation peptide (26 - 101)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (128 - 405)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 419 a.a.
Protein Preferred Names Protein Names

carboxypeptidase A1

  • carboxypeptidase A1 (pancreatic)

Recombinant CPA1 Proteins

Cat. No. Product Name Accession Purity
HY-P7732 Carboxypeptidase A1/CPA1 Protein, Human (HEK293, His) AAH05279.1 (K17-Y419) ≥ 95%, as determined by reducing SDS-PAGE.

CPA1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82741 Carboxypeptidase A1/A2/B Antibody (YA2486) WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Pancreatitis

  • Mumps Pancreatitis
Pancreatitis, Hereditary

  • Hereditary Pancreatitis

  • Chronic Pancreatitis

  • Hereditary Chronic Pancreatitis

  • Hp

  • Pancreatitis, Chronic, Susceptibility To

  • PCTT

  • Hpc

  • Pancreatitis, Chronic

  • Pancreatitis, Chronic, Protection Against

  • Autosomal Dominant Hereditary Pancreatitis

  • Familial Pancreatitis

  • Cp

  • Pancreatitis Hereditary
Spermatogenic Failure 24

  • SPGF24
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Pancreatic Acinar Cell Adenocarcinoma

  • Pancreatic Acinar Cell Carcinoma

  • Acinar Cell Adenocarcinoma Of The Pancreas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10231 Ac-Phe-Thiaphe-OH / Unkown
HY-RS03080 CPA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18609 Cpa1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25095 Cpa1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CPA1 VGNC VGNC:39543
Bos taurus CPA1 VGNC VGNC:27642
Mus musculus CPA1 MGD MGI:88478
Macaca mulatta CPA1 VGNC VGNC:71455
Rattus norvegicus CPA1 RGD RGD:2388
Felis catus CPA1 VGNC VGNC:61111
Others CPA1 NCBI