CPB1 - carboxypeptidase B1 Gene

Also Known as CPB; PASP; PCPB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1360

About CPB1

Cytogenetic location: 3q24 Genomic coordinates (GRCh38): 3:148,827,811-148,860,187 (from NCBI)

This gene has 10 transcripts (splice variants), 220 orthologues and 8 paralogues. Restricted expression toward pancreas (RPKM 27892.6).

Summary

Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each Other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008]

CPB1 Products (1)

mRNA Protein Name
NM_001871.3 NP_001862.2 carboxypeptidase B preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables carboxypeptidase activity IDA
IDA: Inferred from direct assay
1370825 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within proteolysis IDA
IDA: Inferred from direct assay
1370825 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPB1 Protein Structure

Propep_M14

Propep_M14: Carboxypeptidase activation peptide (28 - 104)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (125 - 403)

  • 0
  • 100
  • 200
  • 300
  • 417 a.a.
Protein Preferred Names Protein Names

carboxypeptidase B

  • carboxypeptidase B1 (tissue)

Recombinant CPB1 Proteins

Cat. No. Product Name Accession Purity
HY-P7734 Carboxypeptidase B1/CPB1 Protein, Human (HEK293, His) P15086/NP_001862.2 (H16-Y417) ≥ 95%, as determined by reducing SDS-PAGE.

CPB1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82741 Carboxypeptidase A1/A2/B Antibody (YA2486) WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Acute Pancreatitis

  • Pancreatitis

  • Pancreatitis, Acute Necrotizing

  • Pancreatitis Nos

  • Acute Pancreas Inflammation
Pancreatitis

  • Mumps Pancreatitis
Alcoholic Pancreatitis

  • Pancreatitis, Alcoholic

  • Pancreatitis Alcoholic
Gas Gangrene

  • Myonecrosis

  • Gas Bacillus Infection

  • Gas Gangrene Due To Clostridia

  • Clostridial Myonecrosis

  • Clostridial Cellulitis
Cardiomyopathy, Familial Hypertrophic, 10

  • Hypertrophic Cardiomyopathy 10

  • CMH10

  • Cardiomyopathy, Hypertrophic, Mid-Left Ventricular Chamber Type, 2

  • Cardiomyopathy, Hypertrophic, 10

  • Cardiomyopathy, Familial Hypertrophic 10

  • Familial Hypertrophic Cardiomyopathy With Mid-Left Ventricular Chamber Type 2

  • Mvc2

  • Cardiomyopathy, Hypertrophic, Familial, Type 10
C Syndrome

  • Opitz Trigonocephaly Syndrome

  • Trigonocephaly

  • Trigonocephaly Syndrome

  • Trigonocephaly C Syndrome

  • Opitz C Trigonocephaly

  • Opitz Trigonocephaly C Syndrome

  • Otcs

  • CSYN
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03087 CPB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18610 Cpb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25096 Cpb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CPB1 VGNC VGNC:27645
Mus musculus CPB1 MGD MGI:1923953
Canis familiaris CPB1 VGNC VGNC:39549
Felis catus CPB1 VGNC VGNC:61117
Macaca mulatta CPB1 VGNC VGNC:110372
Rattus norvegicus CPB1 RGD RGD:2391
Others CPB1 NCBI