Mark2 - MAP/microtubule affinity regulating kinase 2 Gene

Also Known as Emk; EMK-1; Par-1; Par-1b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13728

Summary

Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and protein kinase activity. Predicted to be involved in several processes, including generation of neurons; protein phosphorylation; and regulation of neuron projection development. Predicted to act upstream of or within Wnt signaling pathway; cell differentiation; and phosphorylation. Located in basal cortex and nucleus. Is expressed in brain; early conceptus; and oocyte. Orthologous to human MARK2 (microtubule affinity regulating kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Mark2 Products (7)

mRNA Protein Name
NM_001080388.3 NP_001073857.1 serine/threonine-protein kinase MARK2 isoform 2
NM_001080389.3 NP_001073858.1 serine/threonine-protein kinase MARK2 isoform 3
NM_001080390.3 NP_001073859.1 serine/threonine-protein kinase MARK2 isoform 4
NM_001410248.1 NP_001397177.1 serine/threonine-protein kinase MARK2 isoform 5
NM_001410249.1 NP_001397178.1 serine/threonine-protein kinase MARK2 isoform 6
NM_001410250.1 NP_001397179.1 serine/threonine-protein kinase MARK2 isoform 7
NM_007928.4 NP_031954.2 serine/threonine-protein kinase MARK2 isoform 1

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in basal cortex IDA
IDA: Inferred from direct assay
15950600 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21865452 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15950600 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
21865452 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase MARK2

  • ELKL motif kinase 1

  • PAR1 homolog b

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-182743 OICR19451 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mark2 NCBI NCBI:2011