Endog - endonuclease G Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13804

Summary

Predicted to enable endoribonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Acts upstream of or within several processes, including apoptotic DNA fragmentation; in utero embryonic development; and response to tumor necrosis factor. Located in mitochondrion. Is expressed in several structures, including central nervous system; gut; liver; male reproductive gland or organ; and respiratory system. Orthologous to human ENDOG (Endonuclease G). [provided by Alliance of Genome Resources, Apr 2022]

Endog Products (1)

mRNA Protein Name
NM_007931.1 NP_031957.1 endonuclease G, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA endonuclease activity IDA
IDA: Inferred from direct assay
32095813 MGI
enables DNA endonuclease activity IMP
IMP: Inferred from mutant phenotype
25355512 MGI
enables magnesium ion binding IDA
IDA: Inferred from direct assay
32095813 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
33473107 MGI
enables protein homodimerization activity IMP
IMP: Inferred from mutant phenotype
32192768 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic DNA fragmentation IMP
IMP: Inferred from mutant phenotype
14663139 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
14663139 MGI
involved in negative regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
33473107 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
14663139 MGI
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
33473107 MGI
acts upstream of or within response to antibiotic IMP
IMP: Inferred from mutant phenotype
14663139 MGI
acts upstream of or within response to tumor necrosis factor IMP
IMP: Inferred from mutant phenotype
14663139 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endonuclease G, mitochondrial

  • endo G

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-176835 PNR-3-80 Inhibitor 98.63% Unkown
HY-176836 PNR-3-82 Inhibitor 99.08% Unkown
HY-RS04371 ENDOG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19189 Endog Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25677 Endog Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Endog NCBI NCBI:2021