ENDOG - endonuclease G Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2021

About ENDOG

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,818,500-128,822,676 (from NCBI)

This gene has 1 transcript (splice variant), 180 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 10.6), prostate (RPKM 9.4) and 25 other tissues.

Summary

The protein encoded by this gene is a nuclear encoded Endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among Animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA Polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]

ENDOG Products (1)

mRNA Protein Name
NM_004435.2 NP_004426.2 endonuclease G, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA endonuclease activity IMP
IMP: Inferred from mutant phenotype
25355512 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25036637 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
33473107 GOA
involved in mitochondrial DNA catabolic process IMP
IMP: Inferred from mutant phenotype
29719607 GOA
involved in negative regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
33473107 GOA
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
33473107 GOA
involved in positive regulation of mitochondrial DNA replication IMP
IMP: Inferred from mutant phenotype
29719607 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
33473107 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENDOG Protein Structure

Endonuclease_NS

Endonuclease_NS: DNA/RNA non-specific endonuclease (78 - 282)

  • 0
  • 100
  • 200
  • 297 a.a.
Protein Preferred Names Protein Names

endonuclease G, mitochondrial

  • endo G

ENDOG Antibodies

Cat. No. Product Name Application Reactivity
HY-P810871 ENDOG Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P81784 Endo G Antibody (YA1529) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-176835 PNR-3-80 Inhibitor 98.63% Unkown
HY-176836 PNR-3-82 Inhibitor 99.08% Unkown
HY-RS04371 ENDOG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19189 Endog Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25677 Endog Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ENDOG VGNC VGNC:61859
Bos taurus ENDOG VGNC VGNC:28491
Mus musculus ENDOG MGD MGI:1261433
Macaca mulatta ENDOG VGNC VGNC:72218
Rattus norvegicus ENDOG RGD RGD:1310763
Canis familiaris ENDOG VGNC VGNC:40360
Others ENDOG NCBI