Ephb3 - Eph receptor B3 Gene

Also Known as Etk2; HEK2; MDK5; Sek4; Cek10; Tyro6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13845

Summary

Enables axon guidance receptor activity. Involved in several processes, including corpus callosum development; neuron projection development; and tube morphogenesis. Acts upstream of or within central nervous system projection neuron axonogenesis and retinal ganglion cell axon guidance. Predicted to be located in cell projection and plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart; and sensory organ. Orthologous to human EphB3 (EPH receptor B3). [provided by Alliance of Genome Resources, Apr 2022]

Ephb3 Products (1)

mRNA Protein Name
NM_010143.1 NP_034273.1 ephrin type-B receptor 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables axon guidance receptor activity IDA
IDA: Inferred from direct assay
11532925 MGI
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IMP
IMP: Inferred from mutant phenotype
9990854 MGI
acts upstream of or within axon guidance IDA
IDA: Inferred from direct assay
11532925 MGI
involved in axon guidance IMP
IMP: Inferred from mutant phenotype
8947026 MGI
involved in axonal fasciculation IMP
IMP: Inferred from mutant phenotype
8947026 MGI
involved in cell migration IMP
IMP: Inferred from mutant phenotype
12408869 MGI
acts upstream of or within central nervous system projection neuron axonogenesis IDA
IDA: Inferred from direct assay
12971893 MGI
involved in corpus callosum development IMP
IMP: Inferred from mutant phenotype
8947026 MGI
involved in dendritic spine development IMP
IMP: Inferred from mutant phenotype
14691139 MGI
involved in dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
14691139 MGI
involved in digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
12408869 MGI
involved in positive regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
14691139 MGI
involved in regulation of axonogenesis IDA
IDA: Inferred from direct assay
17719550 MGI
acts upstream of or within retinal ganglion cell axon guidance IDA
IDA: Inferred from direct assay
12971893 MGI
involved in roof of mouth development IMP
IMP: Inferred from mutant phenotype
8947026 MGI
involved in thymus development IMP
IMP: Inferred from mutant phenotype
19598115 MGI
involved in urogenital system development IMP
IMP: Inferred from mutant phenotype
15223334 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ephrin type-B receptor 3

  • developmental kinase 5

  • mDK-5

  • tyrosine-protein kinase receptor SEK-4

Recombinant Ephb3 Proteins

Cat. No. Product Name Accession Purity
HY-P75749 EphB3 Protein, Mouse (508a.a, HEK293, His) P54754/NP_034273.1 (L30-T537) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78294 EphB3 Protein, Mouse (HEK293, His) P54754 (L30-L554) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107460 LDN-211904 oxalate Inhibitor 99.0% Unkown
HY-P5438 Srctide Substrate 99.71% Unkown
HY-170517 PKMYT1-IN-8 Inhibitor 99.31% Unkown
HY-RS17657 Ephb3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-136358 LDN-211904 Inhibitor / Unkown
HY-146375 UniPR505 Antagonist 99.68% Unkown
HY-121682 N-(2-Chlorophenyl)-1H-indole-3-carboxamide / Unkown
HY-RS04435 EPHB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24118 Ephb3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991975 Anti-EphB3 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ephb3 NCBI NCBI:2049