EPHB3 - EPH receptor B3 Gene

Also Known as EK2; ETK2; HEK2; TYRO6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2049

About EPHB3

Cytogenetic location: 3q27.1 Genomic coordinates (GRCh38): 3:184,561,785-184,582,408 (from NCBI)

This gene has 3 transcripts (splice variants), 268 orthologues and 53 paralogues. Broad expression in skin (RPKM 18.6), stomach (RPKM 10.2) and 15 other tissues.

Summary

Ephrin receptors and their ligands, the Ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]

EPHB3 Products (1)

mRNA Protein Name
NM_004443.4 NP_004434.2 ephrin type-B receptor 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ephrin receptor activity IDA
IDA: Inferred from direct assay
8397371 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in cell migration IDA
IDA: Inferred from direct assay
15536074 GOA
involved in ephrin receptor signaling pathway IDA
IDA: Inferred from direct assay
8397371 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
8397371 GOA
involved in regulation of GTPase activity IDA
IDA: Inferred from direct assay
15536074 GOA
involved in regulation of cell-cell adhesion IDA
IDA: Inferred from direct assay
8397371 GOA
involved in substrate adhesion-dependent cell spreading IDA
IDA: Inferred from direct assay
15536074 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
8397371 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPHB3 Protein Structure

Ephrin_lbd

Ephrin_lbd: Ephrin receptor ligand binding domain (39 - 212)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (279 - 316)

fn3

fn3: Fibronectin type III domain (341 - 432)

fn3

fn3: Fibronectin type III domain (456 - 535)

EphA2_TM

EphA2_TM: Ephrin type-A receptor 2 transmembrane domain (559 - 630)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (634 - 892)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (924 - 987)

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  • 200
  • 400
  • 600
  • 800
  • 998 a.a.
Protein Preferred Names Protein Names

ephrin type-B receptor 3

  • EPH-like tyrosine kinase 2

EPHB3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EPHB3 P54753 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
EPHB3 P54753 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
EPHB3 P54753 HPCAL1 Homo sapiens P37235
Y2H Array
32296183
Intra
EPHB3 P54753 HPCAL1 Homo sapiens P37235
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EPHB3 Proteins

Cat. No. Product Name Accession Purity
HY-P77931 EphB3 Protein, Human (HEK293, His) P54753 (G34-L559) ≥ 95%, as determined by Bis-Tris PAGE.

EPHB3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83132 Ephrin Receptor B3 Antibody (YA2877) WB, ICC/IF Human, Mouse, Rat
HY-P83132A Ephrin Receptor B3 Antibody (YA2877)(PBS only) WB, ICC/IF Human, Mouse, Rat
HY-P85147 Ephrin Receptor B3 Antibody (YA4839) WB, IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Craniofrontonasal Syndrome

  • Craniofrontonasal Dysplasia

  • CFNS

  • Cfnd

  • Craniofrontonasal Dysostosis

  • Craniofrontonasal Dystosis

  • Dysplasia, Craniofrontonasal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107460 LDN-211904 oxalate Inhibitor 99.0% Unkown
HY-P5438 Srctide Substrate 99.71% Unkown
HY-170517 PKMYT1-IN-8 Inhibitor 99.31% Unkown
HY-RS17657 Ephb3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-136358 LDN-211904 Inhibitor / Unkown
HY-146375 UniPR505 Antagonist 99.68% Unkown
HY-121682 N-(2-Chlorophenyl)-1H-indole-3-carboxamide / Unkown
HY-RS04435 EPHB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24118 Ephb3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991975 Anti-EphB3 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris EPHB3 VGNC VGNC:40412
Macaca mulatta EPHB3 VGNC VGNC:72242
Felis catus EPHB3 VGNC VGNC:61907
Bos taurus EPHB3 VGNC VGNC:28539
Rattus norvegicus EPHB3 RGD RGD:1305602
Mus musculus EPHB3 MGD MGI:104770
Others EPHB3 NCBI