CRHBP - corticotropin releasing hormone binding protein Gene

Also Known as CRFBP; CRF-BP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1393

About CRHBP

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:76,953,045-76,981,159 (from NCBI)

This gene has 5 transcripts (splice variants) and 201 orthologues. Biased expression in liver (RPKM 36.1), kidney (RPKM 16.1) and 6 other tissues.

Summary

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]

CRHBP Products (1)

mRNA	Protein	Name
NM_001882.4	NP_001873.2	corticotropin-releasing factor-binding protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables corticotropin-releasing hormone binding	IDA IDA: Inferred from direct assay	1846945	GOA
enables corticotropin-releasing hormone binding	IPI IPI: Inferred from physical interaction	18234674	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18234674	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in behavioral response to ethanol	IMP IMP: Inferred from mutant phenotype	21039637	GOA
involved in cellular response to estradiol stimulus	IDA IDA: Inferred from direct assay	15345745	GOA
involved in cellular response to estrogen stimulus	IDA IDA: Inferred from direct assay	15345745	GOA
involved in cellular response to potassium ion	IDA IDA: Inferred from direct assay	21624661	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	15345745	GOA
involved in female pregnancy	IDA IDA: Inferred from direct assay	18559919	GOA
involved in female pregnancy	IEP IEP: Inferred from expression pattern	1846945	GOA
involved in hormone-mediated signaling pathway	IDA IDA: Inferred from direct assay	18234674	GOA
involved in inflammatory response	IDA IDA: Inferred from direct assay	18559919	GOA
involved in negative regulation of corticotropin secretion	IDA IDA: Inferred from direct assay	1846945	GOA
involved in negative regulation of corticotropin-releasing hormone receptor activity	IDA IDA: Inferred from direct assay	18234674	GOA
involved in regulated exocytosis	IDA IDA: Inferred from direct assay	21624661	GOA
involved in regulation of cellular response to stress	IMP IMP: Inferred from mutant phenotype	21039637	GOA
involved in regulation of corticotropin secretion	IDA IDA: Inferred from direct assay	13150566	GOA

Cellular Component GO Annotation	Evidence	References	Source
NOT located in Golgi apparatus	IDA IDA: Inferred from direct assay	21624661	GOA
NOT located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21624661	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	1846945	GOA
located in secretory granule	IDA IDA: Inferred from direct assay	21624661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRHBP Protein Structure

CRF-BP

0
100
200
300
322 a.a.

Protein Preferred Names	Protein Names
corticotropin-releasing factor-binding protein	CRF-binding protein

Recombinant CRHBP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70013	CRHBP Protein, Human (HEK293, His)	P24387 (Y25-L322)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Hypoadrenocorticism, Familial	Addison Disease Primary Adrenocortical Insufficiency Addison'S Disease Adrenal Gland Hypofunction Adrenal Hypoplasia Adrenal Aplasia Addison Disease, Chronic Adrenal Insufficiency Primary Hypoadrenalism Hypoadrenocorticism Familial Autoimmune Addison Disease Autoimmune Adrenalitis Classic Addison Disease Primary Addison Disease Addisons Disease Addison Disease, Susceptibility To Autoimmune Primary Adrenal Insufficiency Addison'S Disease Due To Autoimmunity
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Conn'S Syndrome	Cushing Syndrome Hyperaldosteronism Primary Hyperaldosteronism Hypercortisolism Primary Aldosteronism Cushing'S Syndrome Adrenal Gland Hyperfunction Conn Syndrome Hyperadrenalism Ectopic Acth Syndrome Hyperadrenocorticism Cushing Disease Cushing'S Disease Adrenal Cortex Adenoma Corticotroph Pituitary Adenoma Pituitary Corticotroph Micro-Adenoma Pituitary-Dependent Cushing Syndrome Pituitary Acth Hypersecretion Acth Syndrome, Ectopic Acth-Secreting Pituitary Adenoma Adrenal Hyperfunction Resulting From Pituitary Acth Excess Ectopic Adrenocorticotropic Hormone Syndrome Nodular Primary Adrenocortical Dysplasia Pituitary Dependent Cushing Syndrome Pituitary Cushing Syndrome Pituitary-Dependant Cushing Syndrome Pituitary-Dependant Hypercortisolism Pituitary-Dependant Hypercortisolism Disorder Aldosteronism Primary Acth Syndrome Ectopic Adrenal Cushing'S Syndrome Adrenal Cortical Adenoma Cushing Syndrome Nos Cortisol Hypersecretion Corticoadrenal Hypersecretion Cushing Syndrome Secondary To Ectopic Acth-Secretion Ectopic Cushing Syndrome Hypercortisolism Due To Nonpituitary Tumour Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome Idiopathic Aldosteronism Aldosteronism Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia Primary Aldosteronism Due To Adrenal Hyperplasia
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03167	CRHBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19425	Crhbp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25916	Crhbp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CRHBP	RGD	RGD:2403
Felis catus	CRHBP	VGNC	VGNC:61177
Bos taurus	CRHBP	VGNC	VGNC:27708
Mus musculus	CRHBP	MGD	MGI:88497
Macaca mulatta	CRHBP	VGNC	VGNC:71491
Canis familiaris	CRHBP	VGNC	VGNC:39610
Others	CRHBP	NCBI