Etv6 - ets variant 6 Gene

Also Known as Tel

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14011

Summary

This gene encodes a transcriptional repressor belonging to the ETS family of proteins. Knockout of this gene in mice results in embryonic lethality due to defective angiogenesis. In humans, this gene is often involved in chromosome rearrangements associated with specific cancers. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Etv6 Products (2)

mRNA Protein Name
NM_001303102.1 NP_001290031.1 transcription factor ETV6 isoform 2
NM_007961.4 NP_031987.3 transcription factor ETV6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12527908 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17606295 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12527908 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17606295 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12527908 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell differentiation IDA
IDA: Inferred from direct assay
12527908 MGI
acts upstream of or within mesenchymal cell apoptotic process IMP
IMP: Inferred from mutant phenotype
9250681 MGI
acts upstream of or within neurogenesis IMP
IMP: Inferred from mutant phenotype
9250681 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17606295 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12527908 MGI
acts upstream of or within vitellogenesis IMP
IMP: Inferred from mutant phenotype
9250681 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor ETV6

  • ETS-related protein Tel1

  • ets variant gene 6 (TEL oncogene)

  • translocation-ets-leukemia

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-146807 Type II TRK inhibitor 1 Inhibitor / Unkown
HY-155046 FGFR4-IN-14 Inhibitor / Unkown
HY-163366 TRK-IN-28 Inhibitor / Unkown
HY-184598 CYB-5067 / Unkown
HY-RS04569 ETV6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19598 Etv6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26094 Etv6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Etv6 NCBI NCBI:2120