Ext1 - exostosin glycosyltransferase 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14042

Summary

Enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process. Acts upstream of or within with a positive effect on several processes, including glomerular visceral epithelial cell differentiation; heparin biosynthetic process; and nervous system development. Acts upstream of or within with a negative effect on sulfation. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and leukocyte migration. Is integral component of endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and limb. Used to study autism spectrum disorder and hereditary multiple exostoses. Human ortholog(s) of this gene implicated in chondrosarcoma; hereditary multiple exostoses; and trichorhinophalangeal syndrome type II. Orthologous to human EXT1 (exostosin Glycosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ext1 Products (1)

mRNA Protein Name
NM_010162.2 NP_034292.2 exostosin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity IDA
IDA: Inferred from direct assay
10639137 MGI
enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity IGI
IGI: Inferred from genetic interaction
10639137 MGI
enables glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity IDA
IDA: Inferred from direct assay
10639137 MGI
enables glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity IGI
IGI: Inferred from genetic interaction
10639137 MGI
enables glycosyltransferase activity IMP
IMP: Inferred from mutant phenotype
10926768 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
22556407 MGI
acts upstream of or within BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
21148566 MGI
acts upstream of or within antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
23733868 MGI
acts upstream of or within axon guidance IGI
IGI: Inferred from genetic interaction
14605369 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
14605369 MGI
acts upstream of or within positive effect axon guidance IMP
IMP: Inferred from mutant phenotype
14605369 MGI
acts upstream of or within basement membrane organization IMP
IMP: Inferred from mutant phenotype
26024086 MGI
acts upstream of or within blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
26295701 MGI
acts upstream of or within bone growth IMP
IMP: Inferred from mutant phenotype
21185280 MGI
acts upstream of or within bone morphogenesis IMP
IMP: Inferred from mutant phenotype
20080592 MGI
acts upstream of or within bone resorption IMP
IMP: Inferred from mutant phenotype
29415886 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
14605369 MGI
acts upstream of or within positive effect brain development IMP
IMP: Inferred from mutant phenotype
14605369 MGI
acts upstream of or within canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
29545125 MGI
acts upstream of or within cartilage development involved in endochondral bone morphogenesis IMP
IMP: Inferred from mutant phenotype
21185280 MGI
acts upstream of or within cell adhesion IMP
IMP: Inferred from mutant phenotype
19850926 MGI
acts upstream of or within cell adhesion mediated by integrin IMP
IMP: Inferred from mutant phenotype
21093315 MGI
acts upstream of or within cell fate commitment IMP
IMP: Inferred from mutant phenotype
20022960 MGI
acts upstream of or within positive effect cell morphogenesis IMP
IMP: Inferred from mutant phenotype
18480751 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
21185280 MGI
acts upstream of or within positive effect cell surface receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15177029 MGI
acts upstream of positive effect cell surface receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
10926768 MGI
acts upstream of or within cellular component organization IMP
IMP: Inferred from mutant phenotype
28445472 MGI
acts upstream of or within cellular response to BMP stimulus IMP
IMP: Inferred from mutant phenotype
20404326 MGI
acts upstream of or within cellular response to fibroblast growth factor stimulus IMP
IMP: Inferred from mutant phenotype
19850926 MGI
acts upstream of or within cellular response to virus IMP
IMP: Inferred from mutant phenotype
25741008 MGI
acts upstream of or within chemokine production IMP
IMP: Inferred from mutant phenotype
23733868 MGI
acts upstream of or within chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
20080592 MGI
acts upstream of or within chondrocyte hypertrophy IMP
IMP: Inferred from mutant phenotype
23958822 MGI
acts upstream of or within chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
20080592 MGI
acts upstream of or within chondroitin sulfate metabolic process IMP
IMP: Inferred from mutant phenotype
32201365 MGI
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
19850926 MGI
acts upstream of or within cranial skeletal system development IMP
IMP: Inferred from mutant phenotype
28445472 MGI
acts upstream of or within dendrite self-avoidance IMP
IMP: Inferred from mutant phenotype
21743013 MGI
acts upstream of or within dendritic cell migration IMP
IMP: Inferred from mutant phenotype
21093315 MGI
acts upstream of or within developmental growth involved in morphogenesis IMP
IMP: Inferred from mutant phenotype
23192691 MGI
acts upstream of or within positive effect embryonic morphogenesis IMP
IMP: Inferred from mutant phenotype
10926768 MGI
acts upstream of or within embryonic skeletal joint development IMP
IMP: Inferred from mutant phenotype
21185280 MGI
acts upstream of or within endochondral bone growth IMP
IMP: Inferred from mutant phenotype
23192691 MGI
acts upstream of or within endochondral bone morphogenesis IGI
IGI: Inferred from genetic interaction
21310272 MGI
acts upstream of or within endochondral bone morphogenesis IMP
IMP: Inferred from mutant phenotype
21310272 MGI
acts upstream of or within endochondral ossification IMP
IMP: Inferred from mutant phenotype
21185280 MGI
acts upstream of or within endoderm development IMP
IMP: Inferred from mutant phenotype
10926768 MGI
acts upstream of or within positive effect endoderm development IMP
IMP: Inferred from mutant phenotype
10926768 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
28859094 MGI
acts upstream of or within epithelium development IMP
IMP: Inferred from mutant phenotype
26024086 MGI
acts upstream of or within fear response IMP
IMP: Inferred from mutant phenotype
22411800 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
22556407 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
20022960 MGI
acts upstream of or within positive effect fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
26295701 MGI
acts upstream of or within fluid transport IGI
IGI: Inferred from genetic interaction
31365577 MGI
acts upstream of or within gastrulation IMP
IMP: Inferred from mutant phenotype
10926768 MGI
acts upstream of or within positive effect gastrulation IMP
IMP: Inferred from mutant phenotype
10926768 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
20022960 MGI
acts upstream of or within glandular epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
29700203 MGI
acts upstream of or within glomerular basement membrane development IMP
IMP: Inferred from mutant phenotype
18480751 MGI
acts upstream of or within hair cycle process IMP
IMP: Inferred from mutant phenotype
25053416 MGI
acts upstream of or within hair follicle morphogenesis IMP
IMP: Inferred from mutant phenotype
25053416 MGI
acts upstream of or within heart contraction IGI
IGI: Inferred from genetic interaction
31365577 MGI
acts upstream of or within heart field specification IMP
IMP: Inferred from mutant phenotype
26295701 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
25202142 MGI
acts upstream of or within hematopoietic stem cell differentiation IMP
IMP: Inferred from mutant phenotype
21148566 MGI
acts upstream of or within hematopoietic stem cell homeostasis IMP
IMP: Inferred from mutant phenotype
25202142 MGI
acts upstream of or within hematopoietic stem cell migration to bone marrow IMP
IMP: Inferred from mutant phenotype
25202142 MGI
involved in heparan sulfate proteoglycan biosynthetic process IDA
IDA: Inferred from direct assay
10639137 MGI
acts upstream of or within heparan sulfate proteoglycan biosynthetic process IMP
IMP: Inferred from mutant phenotype
20080592 MGI
involved in heparan sulfate proteoglycan biosynthetic process IMP
IMP: Inferred from mutant phenotype
10639137 MGI
acts upstream of or within heparin biosynthetic process IGI
IGI: Inferred from genetic interaction
21310272 MGI
acts upstream of or within heparin biosynthetic process IMP
IMP: Inferred from mutant phenotype
21148566 MGI
acts upstream of or within positive effect heparin biosynthetic process IMP
IMP: Inferred from mutant phenotype
10926768 MGI
acts upstream of or within heparin metabolic process IMP
IMP: Inferred from mutant phenotype
26491162 MGI
acts upstream of or within hypersensitivity IMP
IMP: Inferred from mutant phenotype
21093315 MGI
acts upstream of or within leukocyte tethering or rolling IMP
IMP: Inferred from mutant phenotype
21093315 MGI
acts upstream of or within limb joint morphogenesis IMP
IMP: Inferred from mutant phenotype
20404326 MGI
acts upstream of or within lymphocyte adhesion to endothelial cell of high endothelial venule IMP
IMP: Inferred from mutant phenotype
21093315 MGI
acts upstream of or within lymphocyte migration into lymphoid organs IMP
IMP: Inferred from mutant phenotype
21093315 MGI
acts upstream of or within mesenchymal cell differentiation involved in bone development IMP
IMP: Inferred from mutant phenotype
20404326 MGI
acts upstream of or within mesenchyme development IMP
IMP: Inferred from mutant phenotype
28859094 MGI
acts upstream of or within mesoderm development IMP
IMP: Inferred from mutant phenotype
10926768 MGI
acts upstream of or within positive effect mesoderm development IMP
IMP: Inferred from mutant phenotype
10926768 MGI
acts upstream of or within motor behavior IMP
IMP: Inferred from mutant phenotype
22411800 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
23958822 MGI
acts upstream of or within multicellular organismal-level water homeostasis IGI
IGI: Inferred from genetic interaction
31365577 MGI
acts upstream of or within neural crest cell differentiation IMP
IMP: Inferred from mutant phenotype
26295701 MGI
acts upstream of or within neuron projection development IMP
IMP: Inferred from mutant phenotype
21743013 MGI
acts upstream of or within olfactory bulb development IMP
IMP: Inferred from mutant phenotype
14605369 MGI
acts upstream of or within optic nerve development IMP
IMP: Inferred from mutant phenotype
21743013 MGI
acts upstream of or within ossification involved in bone maturation IMP
IMP: Inferred from mutant phenotype
29415886 MGI
acts upstream of or within perichondral bone morphogenesis IMP
IMP: Inferred from mutant phenotype
28768899 MGI
acts upstream of or within positive effect podocyte differentiation IMP
IMP: Inferred from mutant phenotype
18480751 MGI
acts upstream of or within protein catabolic process IMP
IMP: Inferred from mutant phenotype
22556407 MGI
acts upstream of or within protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
29700203 MGI
acts upstream of or within proteoglycan biosynthetic process IMP
IMP: Inferred from mutant phenotype
21185280 MGI
acts upstream of or within regulation of blood pressure IGI
IGI: Inferred from genetic interaction
31365577 MGI
acts upstream of or within regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
29415886 MGI
acts upstream of or within response to growth factor IMP
IMP: Inferred from mutant phenotype
25202142 MGI
acts upstream of or within response to heparin IMP
IMP: Inferred from mutant phenotype
21148566 MGI
acts upstream of or within response to leukemia inhibitory factor IMP
IMP: Inferred from mutant phenotype
20022960 MGI
acts upstream of or within response to light intensity IMP
IMP: Inferred from mutant phenotype
22411800 MGI
acts upstream of or within response to virus IMP
IMP: Inferred from mutant phenotype
26491162 MGI
acts upstream of or within sebaceous gland development IMP
IMP: Inferred from mutant phenotype
25053416 MGI
acts upstream of or within smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
25053416 MGI
acts upstream of or within smoothened signaling pathway involved in lung development IMP
IMP: Inferred from mutant phenotype
28859094 MGI
acts upstream of or within social behavior IMP
IMP: Inferred from mutant phenotype
22411800 MGI
acts upstream of or within sodium ion homeostasis IGI
IGI: Inferred from genetic interaction
31365577 MGI
acts upstream of or within stem cell division IMP
IMP: Inferred from mutant phenotype
20022960 MGI
acts upstream of or within stomach development IMP
IMP: Inferred from mutant phenotype
29700203 MGI
acts upstream of or within negative effect sulfation IDA
IDA: Inferred from direct assay
18337501 MGI
acts upstream of or within sulfation IMP
IMP: Inferred from mutant phenotype
32201365 MGI
acts upstream of or within sweat gland development IMP
IMP: Inferred from mutant phenotype
25053416 MGI
acts upstream of or within synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
22411800 MGI
acts upstream of or within tight junction organization IMP
IMP: Inferred from mutant phenotype
26024086 MGI
acts upstream of or within vacuole organization IMP
IMP: Inferred from mutant phenotype
18480751 MGI
acts upstream of or within vasodilation IGI
IGI: Inferred from genetic interaction
31365577 MGI
acts upstream of or within vocalization behavior IMP
IMP: Inferred from mutant phenotype
22411800 MGI
acts upstream of or within wound healing IMP
IMP: Inferred from mutant phenotype
26024086 MGI
Cellular Component GO Annotation Evidence References Source
is active in Golgi apparatus IDA
IDA: Inferred from direct assay
10639137 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
9620772 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

exostosin-1

  • exostoses (multiple) 1

  • glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

  • multiple exostoses protein 1 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04607 EXT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21339 Ext1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27858 Ext1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ext1 NCBI NCBI:2131