Abcc3 - ATP binding cassette subfamily C member 3 Gene

Also Known as Mlp2; Mrp3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 140668

Summary

Enables ABC-type bile acid transporter activity. Involved in several processes, including anion transport; response to estradiol; and response to lipopolysaccharide. Acts upstream of or within canalicular bile acid transport. Located in basolateral plasma membrane. Biomarker of several diseases, including bilirubin metabolic disorder (multiple); fatty liver disease (multiple); hepatocellular carcinoma; hyperprolactinemia; and kidney disease (multiple). Orthologous to human ABCC3 (ATP binding cassette subfamily C member 3). [provided by Alliance of Genome Resources, Apr 2022]

Abcc3 Products (1)

mRNA Protein Name
NM_080581.2 NP_542148.2 ATP-binding cassette sub-family C member 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ABC-type bile acid transporter activity IDA
IDA: Inferred from direct assay
10644759 RGD
enables ATPase-coupled transmembrane transporter activity IDA
IDA: Inferred from direct assay
10362653 RGD
Biological Process GO Annotation Evidence References Source
involved in bile acid and bile salt transport IMP
IMP: Inferred from mutant phenotype
10644759 RGD
acts upstream of or within canalicular bile acid transport IDA
IDA: Inferred from direct assay
10362653 RGD
involved in monoatomic anion transmembrane transport IDA
IDA: Inferred from direct assay
11837698 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
16554369 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18505788 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18648771 RGD
involved in response to tetrachloromethane IEP
IEP: Inferred from expression pattern
17544377 RGD
involved in transmembrane transport IMP
IMP: Inferred from mutant phenotype
12909565 RGD
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
11897632 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
18698235 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-binding cassette sub-family C member 3

canalicular multispecific organic anion transporter 2

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 3

  • ATP-binding cassette, subfamily C (CFTR/MRP), member 3

  • MLP-2

  • MRP-like protein 2

  • multidrug resistance protein 3

  • multidrug resistance-associated protein 3

  • organic anion transporter

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0488A Vincristine 98.60% Yes

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2382 Polyphyllin H Inhibitor 99.89% Unkown
HY-RS00062 ABCC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19977 Abcc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26480 Abcc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abcc3 NCBI NCBI:8714