Napa - NSF attachment protein alpha Gene

Also Known as alpha-SNAP

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 140673

Summary

Enables syntaxin binding activity. Involved in positive regulation of ATPase activity and protein-containing complex disassembly. Located in terminal bouton. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. Is active in postsynapse and presynapse. Orthologous to human NAPA (NSF attachment protein alpha). [provided by Alliance of Genome Resources, Apr 2022]

Napa Products (1)

mRNA Protein Name
NM_080585.2 NP_542152.1 alpha-soluble NSF attachment protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SNARE binding IDA
IDA: Inferred from direct assay
7553862 RGD
enables SNARE binding IPI
IPI: Inferred from physical interaction
11931741 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9243506 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
11931741 RGD
enables syntaxin binding IDA
IDA: Inferred from direct assay
11931741 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of ATP-dependent activity IDA
IDA: Inferred from direct assay
11931741 RGD
involved in protein-containing complex disassembly IDA
IDA: Inferred from direct assay
11931741 RGD
Cellular Component GO Annotation Evidence References Source
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
11718992 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
11718992 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
11718992 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
11718992 RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex IDA
IDA: Inferred from direct assay
7553862 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-soluble NSF attachment protein

  • N-ethylmaleimide sensitive fusion protein attachment protein alpha

  • N-ethylmaleimide-sensitive factor attachment protein, alpha

  • SNAP-alpha

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1109 N-Acetylprocainamide Inhibitor 99.89% Yes

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101433 N-Acetylprocainamide hydrochloride Inhibitor 99.83% Yes
HY-RS09029 NAPA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09034 NAPSA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18143 Napa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24618 Napa Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Napa NCBI NCBI:8775