Acsl1 - acyl-CoA synthetase long-chain family member 1 Gene

Also Known as Acs; Acas; FACS; Acas1; Facl2; LACS1; LACS 1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14081

Summary

The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Acsl1 Products (4)

mRNA Protein Name
NM_001302163.1 NP_001289092.1 long-chain-fatty-acid--CoA ligase 1
NM_007981.4 NP_032007.2 long-chain-fatty-acid--CoA ligase 1
NM_001302163.1 NP_001289092.1 long-chain-fatty-acid--CoA ligase 1
NM_007981.4 NP_032007.2 long-chain-fatty-acid--CoA ligase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein serine/threonine kinase activator activity IGI
IGI: Inferred from genetic interaction
20667975 MGI
enables protein serine/threonine kinase activator activity IMP
IMP: Inferred from mutant phenotype
20667975 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adiponectin-activated signaling pathway IMP
IMP: Inferred from mutant phenotype
20667975 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
20620995 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

long-chain-fatty-acid--CoA ligase 1

  • acetate-CoA ligase

  • acetyl-CoA synthetase

  • acetyl-Coenzyme A synthetase 1 (ADP forming)

  • arachidonate--CoA ligase

  • fatty acid Coenzyme A ligase, long chain 2

  • long-chain acyl-CoA synthetase 1

  • phytanate--CoA ligase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0723 Neomangiferin 99.80% Unkown
HY-186096 LP-856866 99.92% Unkown
HY-186095 LP-911888 Inhibitor 99.83% Unkown
HY-RS00200 ACSL1 Human Pre-designed siRNA Set A / Unkown
HY-RS16255 Acsl1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS24003 Acsl1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acsl1 NCBI NCBI:2180