Pde11a - phosphodiesterase 11A Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 140928

About Pde11a

Primary_assembly 3: 60,913,562-61,297,158 reverse strand.mRatBN7.2:CM026976.1

This gene has 4 transcripts (splice variants), 101 orthologues, 20 paralogues and is associated with 4 phenotypes. Biased expression in Testes (RPKM 28.2), Kidney (RPKM 22.) and 5 other tissues.

Summary

Enables cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of cAMP-mediated signaling and negative regulation of cGMP-mediated signaling. Located in perikaryon. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Orthologous to human PDE11A (phosphodiesterase 11A). [provided by Alliance of Genome Resources, Apr 2022]

Pde11a Products (3)

mRNA Protein Name
NM_001127480.2 NP_001120952.1 dual 3',5'-cyclic-AMP and #NAME? phosphodiesterase 11A isoform 3
NM_080893.2 NP_543169.1 dual 3',5'-cyclic-AMP and #NAME? phosphodiesterase 11A isoform 4
NM_001127481.3 NP_001120953.1 dual 3',5'-cyclic-AMP and #NAME? phosphodiesterase 11A isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cAMP/PKA signal transduction IDA
IDA: Inferred from direct assay
11502204 RGD
involved in negative regulation of cGMP-mediated signaling IDA
IDA: Inferred from direct assay
11502204 RGD
Cellular Component GO Annotation Evidence References Source
located in perikaryon IDA
IDA: Inferred from direct assay
19445908 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pde11a Protein Structure

GAF

GAF: smart00065 (216 - 379)

GAF

GAF: smart00065 (401 - 567)

PDEase_I

PDEase_I: pfam00233 (662 - 897)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 935 a.a.
Protein Preferred Names Protein Names

dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

  • cAMP and cGMP phosphodiesterase 11A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156434 PDE11A4-IN-1 Inhibitor / Unkown
HY-181589 PDE11A4-IN-2 Inhibitor / Unkown
HY-RS10202 PDE11A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10203 Pde11a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10204 Pde11a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180869 PDE11A modulator-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde11a NCBI NCBI:50940