Fbn2 - fibrillin 2 Gene

Also Known as sy; sne; Fib-2; mKIAA4226

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14119

Summary

Predicted to be an extracellular matrix structural constituent. Involved in several processes, including bone trabecula formation; positive regulation of osteoblast differentiation; and sequestering of TGFbeta in extracellular matrix. Acts upstream of or within embryonic limb morphogenesis. Located in extracellular region and microfibril. Is expressed in several structures, including connective tissue; embryo mesenchyme; genitourinary system; heart; and respiratory system. Used to study distal arthrogryposis. Human ortholog(s) of this gene implicated in congenital contractural arachnodactyly and scoliosis. Orthologous to human FBN2 (fibrillin 2). [provided by Alliance of Genome Resources, Apr 2022]

Fbn2 Products (1)

mRNA Protein Name
NM_010181.2 NP_034311.2 fibrillin-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hormone activity IDA
IDA: Inferred from direct assay
32329225 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
25762570 MGI
Biological Process GO Annotation Evidence References Source
involved in bone trabecula formation IMP
IMP: Inferred from mutant phenotype
20855508 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
11285249 MGI
involved in glucose homeostasis IDA
IDA: Inferred from direct assay
32329225 MGI
acts upstream of or within limb morphogenesis IMP
IMP: Inferred from mutant phenotype
10700192 MGI
involved in positive regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
20855508 MGI
involved in positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
20855508 MGI
involved in sequestering of TGFbeta in extracellular matrix IMP
IMP: Inferred from mutant phenotype
20855508 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
24348270 MGI
located in microfibril IDA
IDA: Inferred from direct assay
24348270 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibrillin-2

  • syndatyly ems

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04777 FBN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22168 Fbn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28690 Fbn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fbn2 NCBI NCBI:2201