Lgr5 - leucine rich repeat containing G protein coupled receptor 5 Gene

Also Known as FEX; Gpr49

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14160

Summary

The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. [provided by RefSeq, Sep 2015]

Lgr5 Products (1)

mRNA Protein Name
NM_010195.2 NP_034325.2 leucine-rich repeat-containing G-protein coupled receptor 5 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables transmembrane signaling receptor activity IDA
IDA: Inferred from direct assay
21727895 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within epithelial cell proliferation involved in renal tubule morphogenesis IGI
IGI: Inferred from genetic interaction
24680895 MGI
acts upstream of or within hair follicle development IGI
IGI: Inferred from genetic interaction
24680895 MGI
acts upstream of or within inner ear development IDA
IDA: Inferred from direct assay
21795542 MGI
acts upstream of or within oocyte differentiation IMP
IMP: Inferred from mutant phenotype
25158167 MGI
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
21727895 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
25535395 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine-rich repeat-containing G-protein coupled receptor 5

  • G protein-coupled receptor 49

  • follicle expressed hormone

  • orphan G-protein coupled receptor FEX

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99406 Petosemtamab Degrader 99.94% Phase 3

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10810 QPH-FR Inhibitor 99.54% Unkown
HY-RS07619 LGR5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20763 Lgr5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27277 Lgr5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99406A Petosemtamab (FUT8-KO) Degrader 99% Unkown
HY-P991454 Anti-LGR5/GPR49 Antibody (18G7H6A3) Inhibitor 98.64% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lgr5 NCBI NCBI:8549