Fhit - fragile histidine triad gene Gene

Also Known as Fra14A2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14198

Summary

This gene encodes a member of the HIT family of proteins that are characterized by the presence of a histidine triad sequence. The encoded protein is a diadenosine triphosphate hydrolase enzyme that cleaves the P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. This locus is very fragile and has been found to be altered in different types of cancers. Mice lacking the encoded protein display increased susceptibility to spontaneous and induced tumors. Ectopic expression of the encoded protein in such knockout mice inhibits tumor development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Fhit Products (4)

mRNA Protein Name
NM_001308285.1 NP_001295214.1 bis(5'-adenosyl)-triphosphatase isoform 1
NM_001308286.1 NP_001295215.1 bis(5'-adenosyl)-triphosphatase isoform 2
NM_001360141.1 NP_001347070.1 bis(5'-adenosyl)-triphosphatase isoform 2
NM_010210.3 NP_034340.1 bis(5'-adenosyl)-triphosphatase isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA replication IDA
IDA: Inferred from direct assay
15254237 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9699672 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bis(5'-adenosyl)-triphosphatase

  • AP3A hydrolase

  • AP3Aase

  • adenosine 5'-monophosphoramidase FHIT

  • adenylylsulfatase

  • adenylylsulfate-ammonia adenylyltransferase

  • diadenosine 5',5'''-P1,P3-triphosphate hydrolase

  • dinucleosidetriphosphatase

  • fragile histidine triad protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04933 FHIT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-158845 8Br-HA Inducer / Unkown
HY-RS19329 Fhit Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25820 Fhit Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fhit NCBI NCBI:2272