Fkbp10 - FK506 binding protein 10 Gene

Also Known as Fkbp6; FKBP65; Fkbprp; FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14230

Summary

Enables FK506 binding activity and peptidyl-prolyl cis-trans isomerase activity. Acts upstream of or within several processes, including aorta morphogenesis; extracellular matrix organization; and peptidyl-amino acid modification. Located in endoplasmic reticulum; membrane; and mitochondrial intermembrane space. Is expressed in several structures, including connective tissue; intestine epithelium; lung; metanephros; and skeleton. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 11. Orthologous to human FKBP10 (FKBP prolyl isomerase 10). [provided by Alliance of Genome Resources, Apr 2022]

Fkbp10 Products (2)

mRNA Protein Name
NM_001163481.1 NP_001156953.1 peptidyl-prolyl cis-trans isomerase FKBP10 isoform 2 precursor
NM_010221.2 NP_034351.2 peptidyl-prolyl cis-trans isomerase FKBP10 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables FK506 binding IDA
IDA: Inferred from direct assay
7493967 MGI
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: Inferred from direct assay
7493967 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within aorta morphogenesis IMP
IMP: Inferred from mutant phenotype
24777781 MGI
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
24777781 MGI
acts upstream of or within extracellular matrix assembly IMP
IMP: Inferred from mutant phenotype
28774593 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
24777781 MGI
acts upstream of or within peptidyl-lysine hydroxylation IMP
IMP: Inferred from mutant phenotype
24777781 MGI
acts upstream of or within peptidyl-proline modification IDA
IDA: Inferred from direct assay
7493967 MGI
acts upstream of or within wound healing IMP
IMP: Inferred from mutant phenotype
28774593 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
24777781 MGI
located in membrane IDA
IDA: Inferred from direct assay
7493967 MGI
located in mitochondrial intermembrane space IDA
IDA: Inferred from direct assay
25002142 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase FKBP10

  • 65 kDa FK506-binding protein

  • 65 kDa FKBP

  • FK506 binding protein 6 (65 kDa)

  • PPIase FKBP10

  • immunophilin FKBP65

  • rotamase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04956 FKBP10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18709 Fkbp10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25196 Fkbp10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fkbp10 NCBI NCBI:60681