CSH1 - chorionic somatomammotropin hormone 1 Gene

Also Known as PL; CSA; CS-1; CSMT; GHB3; hCS-1; hCS-A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1442

About CSH1

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,894,918-63,896,574 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and 5 paralogues. Restricted expression toward placenta (RPKM 9553.7).

Summary

The protein encoded by this gene is a member of the somatotropin/Prolactin family of Hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four Other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth Hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin Hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]

CSH1 Products (1)

mRNA Protein Name
NM_001317.6 NP_001308.1 chorionic somatomammotropin hormone 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25009770 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
6930851 GOA
located in vesicle IDA
IDA: Inferred from direct assay
6930851 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSH1 Protein Structure

Hormone_1

Hormone_1: Somatotropin hormone family (9 - 215)

  • 0
  • 100
  • 200
  • 217 a.a.
Protein Preferred Names Protein Names

chorionic somatomammotropin hormone 1

  • Chorionic somatomammotropin hormone 2

CSH1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CSH1 P0DML2 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
CSH1 P0DML2 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra
CSH1 P0DML2 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
CSH1 P0DML2 PSMD9 Homo sapiens O00233
ELISA
25009770
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CSH1 Proteins

Cat. No. Product Name Accession Purity
HY-P7871 Placental Lactogen/CSH1 Protein, Human (HEK293, His) P0DML2 (V27-F217) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77147 Placental Lactogen/CSH1 Protein, Human (Biotinylated, HEK293, His) P0DML2 (V27-F217) ≥ 95%, as determined by reducing SDS-PAGE.

CSH1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81446 Placental lactogen Antibody (YA1191) IHC-P Human
HY-P81446A Placental lactogen Antibody (YA1191)(PBS only) IHC-P Human
HY-P85985 Humanm Placental lactogen Antibody (YA5677) IHC-P, ICC/IF, ELISA Human
HY-P86060 Humanm Placental lactogen Antibody (YA5752) IHC-P, ICC/IF, ELISA Human
HY-P87043 Placental lactogen Antibody (YA6736) WB, IHC-P Human, Rat

Related Diseases

Diseases Alias
Choriocarcinoma

  • Chorioepithelioma
Epithelioid Trophoblastic Tumor

  • Trophoblastic Tumor, Epithelioid
Testicular Trophoblastic Tumor
Choriocarcinoma Of Ovary

  • Ovarian Choriocarcinoma
Gestational Choriocarcinoma

  • Gestational Chorionepithelioma

  • Molar Pregnancy With Choriocarcinoma
Non-Gestational Choriocarcinoma

  • Choriocarcinoma, Non-Gestational
Persistent Fetal Circulation Syndrome

  • Persistent Fetal Circulation

  • Fetal Circulation

  • Persistent Pulmonary Hypertension Of The Newborn

  • Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins

  • Persistent Foetal Circulation

  • Persistent Foetal Circulation Syndrome

  • Pfc - [Persistent Fetal Circulation] Syndrome

  • Pphn - [Persistent Pulmonary Hypertension Of The Newborn]

  • Newborn Pulmonary Hypertension

  • Primary Pulmonary Hypertension Of Newborn
Non-Gestational Ovarian Choriocarcinoma
Placental Site Trophoblastic Tumor

  • Trophoblastic Tumor Placental Site

  • Trophoblastic Tumor, Placental Site

  • Placental Site Trophoblastic Tumour

  • Placental-Site Gestational Trophoblastic Neoplasm

  • Placenta Neoplasm

  • Psst

  • Deciduoma

  • Placental Cancer

  • Primary Malignant Neoplasm Of Placenta
Gestational Ovarian Choriocarcinoma
Supine Hypotensive Syndrome

  • Maternal Hypotension Syndrome

  • Antepartum Maternal Hypotension Syndrome

  • Postpartum Maternal Hypotension Syndrome

  • Maternal Hypotension Syndrome, Antepartum Condition Or Complication

  • Maternal Hypotension Syndrome, Postpartum Condition Or Complication

  • Maternal Hypotension Syndrome, Unspecified Trimester
Chronic Interstitial Cystitis
Rete Ovarii Benign Neoplasm
Rete Ovarii Adenoma

  • Adenoma Of Rete Ovarii
Placental Choriocarcinoma

  • Choriocarcinoma Of The Placenta
Corpus Luteum Cyst

  • Cystic Corpus Luteum

  • Luteal Cystic Ovary Disease

  • Lutein Cyst

  • Granulosa Lutein Cyst
Trophoblastic Neoplasm

  • Trophoblastic Tumor

  • Trophoblastic Neoplasms
Rh Isoimmunization

  • Rh Incompatibility Affecting Management Of Mother
Mixed Germ Cell Cancer

  • Mixed Germ Cell Tumor

  • Mixed Germ Cell Neoplasm

  • Mixed Germ Cell Tumour

  • Mixed Teratoma And Seminoma
Gestational Trophoblastic Neoplasm

  • Hydatidiform Mole

  • Molar Pregnancy

  • Gestational Trophoblastic Neoplasia

  • Gestational Trophoblastic Tumor

  • Gtn

  • Gestational Trophoblastic Disease

  • Gestational Trophoblastic Neoplasms

  • Hydatidiform Mole, Recurrent, 1

  • Hydatidiform Mole Benign

  • Trophoblastic Disease

  • Trophoblastic Disease Nos

  • Trophoblastic Disorder

  • Vesicular Mole Nos

  • Vesicular Mole

  • Hydatidiform Mole Nos
Placenta Disease

  • Placenta Diseases

  • Placenta Disorder

  • Pregnancy Complications

  • Placenta Disorders
Ectopic Pregnancy

  • Eccyesis

  • Pregnancy Ectopic

  • Pregnancy, Ectopic

  • Ectopic Pregnancies

  • Extrauterine Gestation Or Pregnancy

  • Extrauterine Pregnancy

  • Ep - [Ectopic Pregnancy]

  • Ectopic Mole

  • Aborted Ectopic Pregnancy

  • Ruptured Ectopic Pregnancy
Pre-Eclampsia

  • Preeclampsia

  • Gestational Hypertension

  • Hypertension Induced By Pregnancy

  • Pre-Eclamptic Toxaemia

  • Pregnancy Associated Hypertension

  • Proteinuric Hypertension Of Pregnancy

  • Hypertension, Pregnancy-Induced, Susceptibility To

  • Preeclampsia/Eclampsia

  • Pregnancy Toxemia

  • Toxaemia Of Pregnancy

  • Gestational Proteinuric Hypertension

  • Pregnancy-Induced Hypertension

  • Toxemia Of Pregnancy

  • Preeclampsia, Susceptibility To

  • Transient Hypertension Of Pregnancy

  • Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

  • Gestational Hypertension Nos

  • Mild Proteinuric Hypertension Of Pregnancy

  • Pih - [Pregnancy-Induced Hypertension]

  • Pregnancy-Induced Hypertension Nos

  • Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

  • Pe - [Pre-Eclampsia]

  • Pre-Eclampsia Nos

  • Pre-Eclamptic Nos

  • Pregnancy Pre-Eclampsia

  • Puerperal Pre-Eclampsia

  • Pre-Eclampsia Toxaemia

  • Toxaemia In Pregnancy

  • Pet - [Pre-Eclamptic Toxaemia]

  • Maternal Toxaemia
Germ Cell And Embryonal Cancer

  • Germ Cell And Embryonal Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03236 CSH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CSH1 MGD MGI:95707