CSH2 - chorionic somatomammotropin hormone 2 Gene

Also Known as PL; CSB; CS-2; GHB1; hCS-B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1443

About CSH2

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,872,012-63,873,729 (from NCBI)

This gene has 7 transcripts (splice variants), 206 orthologues and 5 paralogues. Restricted expression toward placenta (RPKM 5535.3).

Summary

The protein encoded by this gene is a member of the somatotropin/Prolactin family of Hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four Other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth Hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin Hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity. [provided by RefSeq, Jul 2008]

CSH2 Products (3)

mRNA	Protein	Name
NM_020991.4	NP_066271.1	chorionic somatomammotropin hormone 2 isoform 1 precursor
NM_022644.3	NP_072170.1	chorionic somatomammotropin hormone 2 isoform 2 precursor
NM_022645.2	NP_072171.1	chorionic somatomammotropin hormone 2 isoform 3 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	6930851	GOA
located in vesicle	IDA IDA: Inferred from direct assay	6930851	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSH2 Protein Structure

Hormone_1

0
100
200
217 a.a.

Protein Preferred Names	Protein Names
chorionic somatomammotropin hormone 2	choriomammotropin

CSH2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CSH2	P0DML3	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	CSH2	P0DML3	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	CSH2	P0DML3	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	CSH2	P0DML3	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	CSH2	P0DML3	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	CSH2	P0DML3	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

CSH2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86060	Humanm Placental lactogen Antibody (YA5752)	IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Choriocarcinoma	Chorioepithelioma
Epithelioid Trophoblastic Tumor	Trophoblastic Tumor, Epithelioid
Testicular Trophoblastic Tumor
Choriocarcinoma Of Ovary	Ovarian Choriocarcinoma
Gestational Choriocarcinoma	Gestational Chorionepithelioma Molar Pregnancy With Choriocarcinoma
Non-Gestational Choriocarcinoma	Choriocarcinoma, Non-Gestational
Placental Site Trophoblastic Tumor	Trophoblastic Tumor Placental Site Trophoblastic Tumor, Placental Site Placental Site Trophoblastic Tumour Placental-Site Gestational Trophoblastic Neoplasm Placenta Neoplasm Psst Deciduoma Placental Cancer Primary Malignant Neoplasm Of Placenta
Persistent Fetal Circulation Syndrome	Persistent Fetal Circulation Fetal Circulation Persistent Pulmonary Hypertension Of The Newborn Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins Persistent Foetal Circulation Persistent Foetal Circulation Syndrome Pfc - [Persistent Fetal Circulation] Syndrome Pphn - [Persistent Pulmonary Hypertension Of The Newborn] Newborn Pulmonary Hypertension Primary Pulmonary Hypertension Of Newborn
Non-Gestational Ovarian Choriocarcinoma
Gestational Ovarian Choriocarcinoma
Placental Choriocarcinoma	Choriocarcinoma Of The Placenta
Supine Hypotensive Syndrome	Maternal Hypotension Syndrome Antepartum Maternal Hypotension Syndrome Postpartum Maternal Hypotension Syndrome Maternal Hypotension Syndrome, Antepartum Condition Or Complication Maternal Hypotension Syndrome, Postpartum Condition Or Complication Maternal Hypotension Syndrome, Unspecified Trimester
Rete Ovarii Benign Neoplasm
Rete Ovarii Adenoma	Adenoma Of Rete Ovarii
Trophoblastic Neoplasm	Trophoblastic Tumor Trophoblastic Neoplasms
Corpus Luteum Cyst	Cystic Corpus Luteum Luteal Cystic Ovary Disease Lutein Cyst Granulosa Lutein Cyst
Mixed Germ Cell Cancer	Mixed Germ Cell Tumor Mixed Germ Cell Neoplasm Mixed Germ Cell Tumour Mixed Teratoma And Seminoma
Gestational Trophoblastic Neoplasm	Hydatidiform Mole Molar Pregnancy Gestational Trophoblastic Neoplasia Gestational Trophoblastic Tumor Gtn Gestational Trophoblastic Disease Gestational Trophoblastic Neoplasms Hydatidiform Mole, Recurrent, 1 Hydatidiform Mole Benign Trophoblastic Disease Trophoblastic Disease Nos Trophoblastic Disorder Vesicular Mole Nos Vesicular Mole Hydatidiform Mole Nos
Rh Isoimmunization	Rh Incompatibility Affecting Management Of Mother
Placenta Disease	Placenta Diseases Placenta Disorder Pregnancy Complications Placenta Disorders
Immunodeficiency 36	IMD36 Activated Phosphoinositide 3-Kinase Delta Syndrome 2 Immunodeficiency, Type 36
Ectopic Pregnancy	Eccyesis Pregnancy Ectopic Pregnancy, Ectopic Ectopic Pregnancies Extrauterine Gestation Or Pregnancy Extrauterine Pregnancy Ep - [Ectopic Pregnancy] Ectopic Mole Aborted Ectopic Pregnancy Ruptured Ectopic Pregnancy
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Noonan Syndrome With Multiple Lentigines	Leopard Syndrome Multiple Lentigines Syndrome Moynahan Syndrome Cardiomyopathic Lentiginosis Progressive Cardiomyopathic Lentiginosis Cardio-Cutaneous Syndrome Lentiginosis Profusa Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome Generalized Lentiginosis Gorlin Syndrome Ii Lentiginosis Profusa Syndrome Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes Diffuse Lentiginosis Nsml Familial Multiple Lentigines Syndrome Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type Progressive Cardiomyopathic Lentiginosis Syndrome Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Germ Cell And Embryonal Cancer	Germ Cell And Embryonal Neoplasm
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03237	CSH2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CSH2	MGD	MGI:95707