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Gata1 - GATA binding protein 1 Gene

Also Known as Gf-1; eryf1; Gata-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14460

Summary

Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and p53 binding activity. Involved in several processes, including platelet aggregation; regulation of cellular macromolecule biosynthetic process; and regulation of definitive erythrocyte differentiation. Acts upstream of or within several processes, including hemopoiesis; positive regulation of osteoblast proliferation; and regulation of primitive erythrocyte differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; ear; early conceptus; and genitourinary system. Used to study myelodysplastic syndrome; myelofibrosis; and thrombocytopenia. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; X-linked recessive disease (multiple); beta thalassemia; colon adenocarcinoma; and hematologic Cancer (multiple). Orthologous to human GATA1 (GATA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Gata1 Products (3)

mRNA	Protein	Name
NM_001410603.1	NP_001397532.1	erythroid transcription factor
NM_001410604.1	NP_001397533.1	erythroid transcription factor
NM_008089.3	NP_032115.1	erythroid transcription factor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10773455	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8195185	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7896801	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	18063754	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	17505015	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20855530	MGI
enables p53 binding	IPI IPI: Inferred from physical interaction	19411634	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7568177	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8195185	MGI
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	11724781	MGI
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	10438528	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of bone mineralization	IMP IMP: Inferred from mutant phenotype	15005853	MGI
acts upstream of or within cell development	IMP IMP: Inferred from mutant phenotype	9233806	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	9233806	MGI
acts upstream of or within cell-cell signaling	IMP IMP: Inferred from mutant phenotype	15005853	MGI
acts upstream of or within dendritic cell differentiation	IDA IDA: Inferred from direct assay	17505015	MGI
acts upstream of or within embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	9576834	MGI
acts upstream of or within erythrocyte differentiation	IDA IDA: Inferred from direct assay	9427697	MGI
acts upstream of or within erythrocyte differentiation	IGI IGI: Inferred from genetic interaction	9230307	MGI
acts upstream of or within erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	1302015	MGI
involved in erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	10700180	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IGI IGI: Inferred from genetic interaction	14504093	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	9576834	MGI
acts upstream of or within megakaryocyte differentiation	IDA IDA: Inferred from direct assay	9427697	MGI
acts upstream of or within megakaryocyte differentiation	IGI IGI: Inferred from genetic interaction	9230307	MGI
acts upstream of or within megakaryocyte differentiation	IMP IMP: Inferred from mutant phenotype	9233806	MGI
acts upstream of myeloid cell apoptotic process	IMP IMP: Inferred from mutant phenotype	7568185	MGI
acts upstream of or within myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	8901585	MGI
acts upstream of or within negative regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	15005853	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	9233806	MGI
acts upstream of or within negative regulation of myeloid cell apoptotic process	IMP IMP: Inferred from mutant phenotype	7568185	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17505015	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19411634	MGI
acts upstream of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	15005853	MGI
involved in platelet aggregation	IMP IMP: Inferred from mutant phenotype	15701726	MGI
acts upstream of or within platelet formation	IMP IMP: Inferred from mutant phenotype	9233806	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	24245781	MGI
acts upstream of or within positive regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	15005853	MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	15701726	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8195185	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12200364	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19011221	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20133935	MGI
acts upstream of or within primitive erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	9139715	MGI
involved in regulation of definitive erythrocyte differentiation	IDA IDA: Inferred from direct assay	12200364	MGI
involved in regulation of glycoprotein biosynthetic process	IMP IMP: Inferred from mutant phenotype	15701726	MGI
acts upstream of or within regulation of primitive erythrocyte differentiation	IGI IGI: Inferred from genetic interaction	14504093	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17505015	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	7924983	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
erythroid transcription factor	GATA-binding factor 1 NF-E1 DNA-binding protein

Gata1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Gata1	P17679	Lmo2	Mus musculus	P25801	Anti Bait CoIP	7568177
Intra	Gata1	P17679	Zfpm1	Mus musculus	O35615	Anti Bait CoIP	19513100
Intra	Gata1	P17679	Rb1	Mus musculus	P13405	Anti Bait CoIP	19513100
Cross	Gata1	P17679	ush	Drosophila melanogaster	Q9VPQ6	ITC	15644435
Cross	Gata1	P17679	ush	Drosophila melanogaster	Q9VPQ6	NMR	15644435

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3761	Ac-Tyr-Val-Lys-Asp-aldehyde	Inhibitor	99.89%	Unkown
HY-RS05289	GATA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174677	Human GATA1 mRNA		/	Unkown
HY-RS20026	Gata1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26529	Gata1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gata1	NCBI	NCBI:2623