Zfpm1 - zinc finger protein, multitype 1 Gene

Also Known as FOG; Fog1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22761

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including embryonic hemopoiesis; heart development; and negative regulation of cell differentiation. Acts upstream of or within several processes, including myeloid cell differentiation; regulation of chemokine production; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and integumental system. Orthologous to human ZFPM1 (Zinc Finger Protein, FOG family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Zfpm1 Products (1)

mRNA Protein Name
NM_009569.4 NP_033595.1 zinc finger protein ZFPM1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
IDA: Inferred from direct assay
9230307 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9230307 MGI
Biological Process GO Annotation Evidence References Source
involved in atrial septum morphogenesis IMP
IMP: Inferred from mutant phenotype
14614148 MGI
involved in atrioventricular valve morphogenesis IMP
IMP: Inferred from mutant phenotype
14614148 MGI
involved in cardiac muscle tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
14614148 MGI
acts upstream of or within definitive erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
9553047 MGI
involved in embryonic hemopoiesis IMP
IMP: Inferred from mutant phenotype
14614148 MGI
acts upstream of or within erythrocyte differentiation IGI
IGI: Inferred from genetic interaction
9230307 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
20010697 MGI
acts upstream of or within granulocyte differentiation IMP
IMP: Inferred from mutant phenotype
20010697 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
14614148 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
20643340 MGI
acts upstream of or within megakaryocyte development IMP
IMP: Inferred from mutant phenotype
20010697 MGI
acts upstream of or within megakaryocyte differentiation IGI
IGI: Inferred from genetic interaction
9230307 MGI
acts upstream of or within megakaryocyte differentiation IMP
IMP: Inferred from mutant phenotype
9553047 MGI
involved in mitral valve formation IMP
IMP: Inferred from mutant phenotype
14614148 MGI
involved in negative regulation of mast cell differentiation IDA
IDA: Inferred from direct assay
18063754 MGI
involved in negative regulation of protein binding IDA
IDA: Inferred from direct assay
18063754 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
2906112 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20010697 MGI
involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
14614148 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9230307 MGI
acts upstream of or within primitive erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
9553047 MGI
acts upstream of or within regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
20643340 MGI
involved in tricuspid valve formation IMP
IMP: Inferred from mutant phenotype
14614148 MGI
involved in ventricular septum morphogenesis IMP
IMP: Inferred from mutant phenotype
14614148 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12213678 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger protein ZFPM1

  • FOG-1

  • Friend of GATA 1

  • friend of GATA protein 1

Zfpm1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Zfpm1 O35615 Kdm1a Mus musculus Q6ZQ88
Anti Tag CoIP
19654328
Intra
Zfpm1 O35615 Kdm1a Mus musculus Q6ZQ88
TAP
19654328
Intra
Zfpm1 O35615 Tacc3 Mus musculus Q9JJ11
Y2H
15234987
Intra
Zfpm1 O35615 Tacc3 Mus musculus Q9JJ11
NMR
15234987
Intra
Zfpm1 O35615 Tacc3 Mus musculus Q9JJ11
Anti Tag CoIP
15234987
Intra
Zfpm1 O35615 Gata1 Mus musculus P17679
Anti Bait CoIP
19513100
Intra
Zfpm1 O35615 Gata1 Mus musculus P17679
TAP
19654328
Intra
Zfpm1 O35615 Gata1 Mus musculus P17679
Anti Bait CoIP
19654328
Intra
Zfpm1 O35615 Gata1 Mus musculus P17679
Y2H
15234987
Cross
Zfpm1 O35615 GATA1 Homo sapiens P15976
Pull Down
11675338
Cross
Zfpm1 O35615 GATA1 Homo sapiens P15976
Y2H
11675338
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16048 ZFPM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19759 Zfpm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26256 Zfpm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Zfpm1 NCBI NCBI:161882