Kdm1a - lysine (K)-specific demethylase 1A Gene

Also Known as Aof2; Kdm1; Lsd1; mKIAA0601; D4Ertd478e; 1810043O07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 99982

About Kdm1a

Chromosome 4: 136,277,851-136,330,034 reverse strand.GRCm39:CM000997.3

This gene has 9 transcripts (splice variants), 215 orthologues, 9 paralogues and is associated with 39 phenotypes. Ubiquitous expression in CNS E14 (RPKM 42.5), whole brain E14.5 (RPKM 4.5) and 28 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor binding activity; histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity; and promoter-specific chromatin binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of cell population proliferation; and regulation of myeloid cell differentiation. Acts upstream of or within histone H3-K4 demethylation; nervous system development; and positive regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Is expressed in several structures, including brain; inner cell mass; reproductive system; retina; and urinary system. Orthologous to human KDM1A (lysine demethylase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Kdm1a Products (3)

mRNA Protein Name
NM_001347221.1 NP_001334150.1 lysine-specific histone demethylase 1A isoform 1
NM_001356567.1 NP_001343496.1 lysine-specific histone demethylase 1A isoform 3
NM_133872.2 NP_598633.2 lysine-specific histone demethylase 1A isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
20833138 MGI
enables FAD-dependent H3K4me/H3K4me3 demethylase activity IDA
IDA: Inferred from direct assay
24843136 MGI
enables MRF binding IPI
IPI: Inferred from physical interaction
20833138 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
28053041 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
20123967 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
17392792 MGI
enables enzyme binding IPI
IPI: Inferred from physical interaction
17277772 MGI
enables histone H3K4 demethylase activity IMP
IMP: Inferred from mutant phenotype
24217620 MGI
enables histone H3K9me2/H3K9me3 demethylase activity IMP
IMP: Inferred from mutant phenotype
20833138 MGI
enables lncRNA binding IDA
IDA: Inferred from direct assay
27618650 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
19497860 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17296600 MGI
enables transcription coactivator activity IMP
IMP: Inferred from mutant phenotype
20123967 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
17707228 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within DNA repair-dependent chromatin remodeling IDA
IDA: Inferred from direct assay
24217620 MGI
acts upstream of or within cell differentiation IMP
IMP: Inferred from mutant phenotype
17392792 MGI
involved in granulocyte differentiation IMP
IMP: Inferred from mutant phenotype
17707228 MGI
involved in muscle cell development IMP
IMP: Inferred from mutant phenotype
20833138 MGI
acts upstream of or within negative regulation of neurogenesis IDA
IDA: Inferred from direct assay
25018020 MGI
acts upstream of or within negative regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
25018020 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19497860 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17392792 MGI
acts upstream of or within neuron projection extension IGI
IGI: Inferred from genetic interaction
25018020 MGI
acts upstream of or within neuron projection extension IMP
IMP: Inferred from mutant phenotype
25018020 MGI
acts upstream of or within pituitary gland development IMP
IMP: Inferred from mutant phenotype
17392792 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
27566776 MGI
involved in positive regulation of erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
17707228 MGI
involved in positive regulation of megakaryocyte differentiation IMP
IMP: Inferred from mutant phenotype
17707228 MGI
involved in positive regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
20123967 MGI
involved in positive regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
20123967 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17392792 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20123967 MGI
acts upstream of or within regulation of neurogenesis IGI
IGI: Inferred from genetic interaction
25018020 MGI
involved in regulation of primitive erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
17707228 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17392792 MGI
Cellular Component GO Annotation Evidence Références Source
located in chromatin IDA
IDA: Inferred from direct assay
20833138 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19497860 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Kdm1a Protein Structure

PHA03378

PHA03378: cl33729 (38 - 98)

PLN02328

PLN02328: cl33466 (203 - 845)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 873 a.a.
Protein Preferred Names Protein Names

lysine-specific histone demethylase 1A

  • BRAF35-HDAC complex protein BHC110

  • amine oxidase (flavin containing) domain 2

  • flavin-containing amine oxidase domain-containing protein 2

  • lysine (K)-specific demethylase 1

  • lysine-specific histone demethylase 1

Kdm1a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
Kdm1a Q6ZQ88 Rcor1 Mus musculus Q8CFE3
Anti Bait CoIP
17392792
Intra
Kdm1a Q6ZQ88 Cebpa Mus musculus P53566
Anti Bait CoIP
26974661
Intra
Kdm1a Q6ZQ88 Hdac1 Mus musculus O09106
Anti Bait CoIP
26974661
Intra
Kdm1a Q6ZQ88 Hdac1 Mus musculus O09106
Anti Bait CoIP
20404188
Intra
Kdm1a Q6ZQ88 Hdac1 Mus musculus O09106
Anti Bait CoIP
22297846
Intra
Kdm1a Q6ZQ88 Hdac2 Mus musculus P70288
Anti Bait CoIP
20404188
Intra
Kdm1a Q6ZQ88 Rnf2 Mus musculus Q9CQJ4
Anti Bait CoIP
17296600
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)
Cat. No. Nom du produit Effect
Pureté Phase
HY-109117 Iadademstat 99.82% Phase 2
HY-103713 Seclidemstat Inhibitor 99.77% Phase 2
HY-18632A GSK2879552 dihydrochloride Inhibitor 99.82% Phase 2
HY-12782T Iadademstat dihydrochloride Inhibitor 99.98% Phase 1
HY-138830 TAK-418 Inhibitor 99.81% Phase 1
HY-183067 TAS1440 / Phase 1

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-18632 GSK2879552 Inhibitor 99.98% Unkown
HY-19612A DDP-38003 dihydrochloride Inhibitor 99.31% Unkown
HY-103713A Seclidemstat mesylate Inhibitor 99.80% Unkown
HY-RS07205 KDM1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-19612B DDP-38003 trihydrochloride Inhibitor / Unkown
HY-112304 NCD38 TFA Inhibitor / Unkown
HY-112304A (1R,2S)-NCD38 TFA Inhibitor / Unkown
HY-123577 TPC-144 / Unkown
HY-143238 FY-56 Inhibitor / Unkown
HY-183067A TAS1440 benzoate / Unkown
HY-186116 LSD1-IN-49 Inhibitor / Unkown
HY-186116A LSD1-IN-49 hydrochloride Inhibitor / Unkown
HY-19612 DDP-38003 Inhibitor / Unkown
HY-RS07206 Kdm1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07207 Kdm1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm1a NCBI NCBI:23028