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Rnf2 - ring finger protein 2 Gene

Also Known as dinG; Ring1B

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19821

Summary

Enables chromatin binding activity and ubiquitin protein Ligase activity. Involved in germ cell development and histone H2A-K119 monoubiquitination. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including gastrulation with mouth forming second; histone ubiquitination; and negative regulation of transcription by RNA polymerase II. Located in euchromatin; nuclear body; and sex chromatin. Part of PcG protein complex and ubiquitin Ligase complex. Is expressed in several structures, including central nervous system; limb; ovary; retina; and urinary system. Orthologous to human RNF2 (ring finger protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Rnf2 Products (4)

mRNA	Protein	Name
NM_001360844.1	NP_001347773.1	E3 ubiquitin-protein ligase RING2 isoform a
NM_001360845.1	NP_001347774.1	E3 ubiquitin-protein ligase RING2 isoform b
NM_001360847.1	NP_001347776.1	E3 ubiquitin-protein ligase RING2 isoform b
NM_011277.3	NP_035407.1	E3 ubiquitin-protein ligase RING2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	12183370	MGI
enables histone H2AK119 ubiquitin ligase activity	IMP IMP: Inferred from mutant phenotype	24034696	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9627119	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	16359901	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within anterior/posterior axis specification	IMP IMP: Inferred from mutant phenotype	12183370	MGI
acts upstream of or within positive effect chromatin organization	IDA IDA: Inferred from direct assay	16359901	MGI
acts upstream of or within positive effect chromatin organization	IGI IGI: Inferred from genetic interaction	15525528	MGI
acts upstream of or within gastrulation with mouth forming second	IMP IMP: Inferred from mutant phenotype	12589020	MGI
acts upstream of or within negative effect gene expression	IMP IMP: Inferred from mutant phenotype	23027973	MGI
involved in germ cell development	IMP IMP: Inferred from mutant phenotype	23486062	MGI
acts upstream of or within mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	12589020	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16687444	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24034696	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of PRC1 complex	IDA IDA: Inferred from direct assay	16359901	MGI
part of PcG protein complex	IDA IDA: Inferred from direct assay	16624538	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	24980959	MGI
located in euchromatin	IDA IDA: Inferred from direct assay	18311137	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	18311137	MGI
located in nuclear body	IDA IDA: Inferred from direct assay	12183370	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	24980959	MGI
located in nucleus	IDA IDA: Inferred from direct assay	14557078	MGI
located in sex chromatin	IDA IDA: Inferred from direct assay	15525528	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RING2	RING finger protein 1B RING-type E3 ubiquitin transferase RING2

Rnf2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Rnf2	Q9CQJ4	Skp1	Mus musculus	Q9WTX5	Pull Down	17296600
Intra	Rnf2	Q9CQJ4	Skp1	Mus musculus	Q9WTX5	Anti Bait CoIP	17296600
Intra	Rnf2	Q9CQJ4	Kdm2b	Mus musculus	Q6P1G2	Pull Down	17296600
Intra	Rnf2	Q9CQJ4	Kdm2b	Mus musculus	Q6P1G2	Anti Bait CoIP	17296600
Intra	Rnf2	Q9CQJ4	Kdm1a	Mus musculus	Q6ZQ88	Anti Bait CoIP	17296600
Intra	Rnf2	Q9CQJ4	Kdm1a	Mus musculus	Q6ZQ88	Pull Down	17296600
Intra	Rnf2	Q9CQJ4	Csnk2a1	Mus musculus	Q61177	Anti Bait CoIP	17296600
Intra	Rnf2	Q9CQJ4	Csnk2a1	Mus musculus	Q61177	Pull Down	17296600
Intra	Rnf2	Q9CQJ4	Cbx8	Mus musculus	Q9QXV1	Anti Bait CoIP	17296600
Intra	Rnf2	Q9CQJ4	Cbx8	Mus musculus	Q9QXV1	Pull Down	17296600
Intra	Rnf2	Q9CQJ4	Phc2	Mus musculus	Q9QWH1	Anti Bait CoIP	16024804
Intra	Rnf2	Q9CQJ4	Phc2	Mus musculus	Q9QWH1	Pull Down	17296600
Intra	Rnf2	Q9CQJ4	Phc2	Mus musculus	Q9QWH1	Y2H	9627119
Intra	Rnf2	Q9CQJ4	Phc2	Mus musculus	Q9QWH1	Pull Down	16359901
Intra	Rnf2	Q9CQJ4	Pcgf2	Mus musculus	P23798	Anti Bait CoIP	22325148
Intra	Rnf2	Q9CQJ4	Pcgf2	Mus musculus	P23798	Pull Down	17296600
Intra	Rnf2	Q9CQJ4	Pcgf2	Mus musculus	P23798	Y2H	12183370
Intra	Rnf2	Q9CQJ4	Pcgf2	Mus musculus	P23798	Anti Bait CoIP	12183370
Intra	Rnf2	Q9CQJ4	Phc1	Mus musculus	Q64028	Pull Down	17296600
Intra	Rnf2	Q9CQJ4	Phc1	Mus musculus	Q64028	Anti Bait CoIP	22325148
Intra	Rnf2	Q9CQJ4	Phc1	Mus musculus	Q64028	Pull Down	18650381
Intra	Rnf2	Q9CQJ4	Bmi1	Mus musculus	P25916	Pull Down	17296600
Intra	Rnf2	Q9CQJ4	Bmi1	Mus musculus	P25916	Pull Down	18650381
Intra	Rnf2	Q9CQJ4	Bmi1	Mus musculus	P25916	Y2H	9627119
Intra	Rnf2	Q9CQJ4	Bmi1	Mus musculus	P25916	GMS	18650381
Intra	Rnf2	Q9CQJ4	Bmi1	Mus musculus	P25916	Pull Down	16359901
Intra	Rnf2	Q9CQJ4	Bmi1	Mus musculus	P25916	Y2H	12183370
Intra	Rnf2	Q9CQJ4	Rybp	Mus musculus	Q8CCI5	Anti Bait CoIP	10369680
Intra	Rnf2	Q9CQJ4	Rybp	Mus musculus	Q8CCI5	Anti Bait CoIP	22325148
Intra	Rnf2	Q9CQJ4	Ring1	Mus musculus	O35730	Pull Down	16359901
Intra	Rnf2	Q9CQJ4	Ring1	Mus musculus	O35730	Pull Down	17296600
Intra	Rnf2	Q9CQJ4	Ring1	Mus musculus	O35730	Anti Bait CoIP	17296600

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12074	RNF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19947	Rnf2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26449	Rnf2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rnf2	NCBI	NCBI:6045