Phc2 - polyhomeotic 2 Gene

Also Known as p36; Edr2; Mph2; A3galt2; D4Ertd810e; D130050K19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54383

Summary

Predicted to enable chromatin binding activity; histone binding activity; and identical protein binding activity. Acts upstream of or within spermatogenesis. Located in heterochromatin and nucleus. Part of PcG protein complex. Is expressed in several structures, including central nervous system and retina nuclear layer. Orthologous to human PHC2 (polyhomeotic homolog 2). [provided by Alliance of Genome Resources, Apr 2022]

Phc2 Products (3)

mRNA Protein Name
NM_001195083.1 NP_001182012.1 polyhomeotic-like protein 2 isoform B
NM_001195130.1 NP_001182059.1 polyhomeotic-like protein 2 isoform A
NM_018774.4 NP_061244.1 polyhomeotic-like protein 2 isoform A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9627119 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within spermatogenesis IGI
IGI: Inferred from genetic interaction
17215307 MGI
Cellular Component GO Annotation Evidence References Source
part of PRC1 complex IDA
IDA: Inferred from direct assay
16359901 MGI
located in heterochromatin IDA
IDA: Inferred from direct assay
18311137 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12034499 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polyhomeotic-like protein 2

  • early development regulator 2

  • early development regulatory protein 2

  • polyhomeotic 2 protein

  • polyhomeotic-like 2

Phc2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Phc2 Q9QWH1 Mapkapk2 Mus musculus P49138
Pull Down
19369945
Intra
Phc2 Q9QWH1 Mapkapk2 Mus musculus P49138
Y2H
19369945
Intra
Phc2 Q9QWH1 Pcgf2 Mus musculus P23798
Anti Bait CoIP
16024804
Intra
Phc2 Q9QWH1 Pcgf2 Mus musculus P23798
Y2H
12034499
Intra
Phc2 Q9QWH1 Rnf2 Mus musculus Q9CQJ4
Anti Bait CoIP
16024804
Intra
Phc2 Q9QWH1 Phc1 Mus musculus Q64028
Anti Bait CoIP
16024804
Cross
Phc2 Q9QWH1 MAPKAPK2 Homo sapiens P49137
Pull Down
19369945
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10410 PHC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Phc2 NCBI NCBI:1912