Pcgf2 - polycomb group ring finger 2 Gene

Also Known as Mel18; Rnf110; Zfp144; mel-18

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22658

Summary

Enables chromatin binding activity. Acts upstream of or within several processes, including cellular response to hydrogen peroxide; chordate embryonic development; and negative regulation of apoptotic signaling pathway. Located in nuclear body and sex chromatin. Part of PcG protein complex. Is expressed in several structures, including adipose tissue; alimentary system; brain; eye; and genitourinary system. Orthologous to human PCGF2 (polycomb group ring finger 2). [provided by Alliance of Genome Resources, Apr 2022]

Pcgf2 Products (3)

mRNA	Protein	Name
NM_001163307.1	NP_001156779.1	polycomb group RING finger protein 2
NM_001163308.1	NP_001156780.1	polycomb group RING finger protein 2
NM_009545.2	NP_033571.1	polycomb group RING finger protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	15741318	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12034499	MGI
NOT enables ubiquitin-protein transferase activator activity	IDA IDA: Inferred from direct assay	16359901	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	15741318	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	8625838	MGI
acts upstream of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	11290297	MGI
acts upstream of or within cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	20808772	MGI
acts upstream of or within chromatin organization	IGI IGI: Inferred from genetic interaction	16687444	MGI
acts upstream of or within embryonic skeletal system development	IGI IGI: Inferred from genetic interaction	11290297	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IGI IGI: Inferred from genetic interaction	11290297	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	11290297	MGI
acts upstream of or within negative regulation of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	11290297	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	11290297	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of PRC1 complex	IDA IDA: Inferred from direct assay	16359901	MGI
part of PcG protein complex	IDA IDA: Inferred from direct assay	28596365	MGI
located in nuclear body	IDA IDA: Inferred from direct assay	12183370	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12034499	MGI
located in sex chromatin	IDA IDA: Inferred from direct assay	15525528	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
polycomb group RING finger protein 2	DNA-binding protein Mel-18 melanoma nuclear protein 18 ring finger protein 110 zfp-144 zinc finger protein 144

Pcgf2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Pcgf2	P23798	Phc2	Mus musculus	Q9QWH1	Anti Tag CoIP	22325148
Intra	Pcgf2	P23798	Phc2	Mus musculus	Q9QWH1	Y2H	12183370
Intra	Pcgf2	P23798	Rnf2	Mus musculus	Q9CQJ4	Anti Tag CoIP	22325148
Intra	Pcgf2	P23798	Rnf2	Mus musculus	Q9CQJ4	IF	12183370
Intra	Pcgf2	P23798	Rnf2	Mus musculus	Q9CQJ4	Y2H	12183370
Intra	Pcgf2	P23798	Rnf2	Mus musculus	Q9CQJ4	Anti Bait CoIP	22325148
Intra	Pcgf2	P23798	Rnf2	Mus musculus	Q9CQJ4	Anti Tag CoIP	16359901
Intra	Pcgf2	P23798	Rnf2	Mus musculus	Q9CQJ4	Pull Down	12183370
Intra	Pcgf2	P23798	Phc1	Mus musculus	Q64028	Y2H	12183370
Intra	Pcgf2	P23798	Phc1	Mus musculus	Q64028	Anti Tag CoIP	22325148

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10146	PCGF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22710	Pcgf2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pcgf2	NCBI	NCBI:7703