Ring1 - ring finger protein 1 Gene

Also Known as Ring1A

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19763

Summary

Enables chromatin binding activity and ubiquitin-protein transferase activator activity. Acts upstream of or within several processes, including camera-type eye morphogenesis; histone ubiquitination; and negative regulation of transcription, DNA-templated. Located in nuclear body and sex chromatin. Part of PcG protein complex and ubiquitin Ligase complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human RING1 (ring finger protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ring1 Products (1)

mRNA Protein Name
NM_009066.3 NP_033092.3 E3 ubiquitin-protein ligase RING1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
16687444 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10369680 MGI
enables ubiquitin-protein transferase activator activity IDA
IDA: Inferred from direct assay
16359901 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
16624538 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
11060235 MGI
acts upstream of or within camera-type eye morphogenesis IGI
IGI: Inferred from genetic interaction
16624538 MGI
acts upstream of or within positive effect chromatin organization IDA
IDA: Inferred from direct assay
16359901 MGI
acts upstream of or within positive effect chromatin organization IGI
IGI: Inferred from genetic interaction
15525528 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9312051 MGI
Cellular Component GO Annotation Evidence References Source
part of PRC1 complex IDA
IDA: Inferred from direct assay
16359901 MGI
part of PcG protein complex IDA
IDA: Inferred from direct assay
9312051 MGI
located in nuclear body IDA
IDA: Inferred from direct assay
12183370 MGI
located in sex chromatin IDA
IDA: Inferred from direct assay
15525528 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RING1

  • RING-type E3 ubiquitin transferase RING1

  • polycomb complex protein RING1

  • transcription repressor Ring1A

Ring1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ring1 O35730 Cbx8 Mus musculus Q9QXV1
Pull Down
16359901
Intra
Ring1 O35730 Phc2 Mus musculus Q9QWH1
Pull Down
16359901
Intra
Ring1 O35730 Bmi1 Mus musculus P25916
Pull Down
16359901
Intra
Ring1 O35730 Rybp Mus musculus Q8CCI5
Y2H
10369680
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-N16025 DOPE-PEG(2000) Amine ammonium / Phase 1

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139514 RB-3 Inhibitor 99.14% Unkown
HY-160924 MS147 Degrader 98.31% Unkown
HY-170823 PRC1-IN-1 Inhibitor 97.30% Unkown
HY-158239 MS181 Inhibitor 98.36% Unkown
HY-103291 Sar-[D-Phe8]-des-Arg9-Bradykinin Agonist 99.96% Unkown
HY-124467 Difludiazepam Ligand 98.9% Unkown
HY-RS11985 RING1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-116918 N,N-Diphenylacetamide 99.40% Unkown
HY-W507009 L-Arginyl-L-alanine 99.75% Unkown
HY-129665 GS-389 Inhibitor / Unkown
HY-138140 Desertomycin A / Unkown
HY-160562 PROTAC ERα Degrader-7 Degrader / Unkown
HY-N19716 Austamide / Unkown
HY-P3228 JKC 302 Antagonist / Unkown
HY-W160625 3,5-Dimethyl-2-cyclohexen-1-one 99.75% Unkown
HY-183634 BMI1/RING1B ligand-1 / Unkown
HY-N15186 Gymnoascolide A / Unkown
HY-RS18405 Ring1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24886 Ring1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ring1 NCBI NCBI:6015