KDM1A - lysine demethylase 1A Gene

Homo sapiens

Also known as AOF2; CPRF; KDM1; LSD1; BHC110

Gene ID: 23028 | Gene type: protein coding

About KDM1A

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,019,468-23,083,689 (from NCBI)

This gene has 36 transcripts (splice variants), 215 orthologues, 7 paralogues and is associated with 4 phenotypes. Broad expression in testis (RPKM 45.8), endometrium (RPKM 15.8) and 25 other tissues.

Summary

This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a Histone Demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

KDM1A Products(11)

mRNA	Protein	Name
XM_017000717.2	XP_016856206.1	lysine-specific histone demethylase 1A isoform X6
NM_015013.4	NP_055828.2	lysine-specific histone demethylase 1A isoform b
XM_005245786.3	XP_005245843.1	lysine-specific histone demethylase 1A isoform X2
NM_001410762.1	NP_001397691.1	lysine-specific histone demethylase 1A isoform d
NM_001410763.1	NP_001397692.1	lysine-specific histone demethylase 1A isoform e
XM_047449677.1	XP_047305633.1	lysine-specific histone demethylase 1A isoform X5
XM_017000716.2	XP_016856205.1	lysine-specific histone demethylase 1A isoform X4
NM_001363654.2	NP_001350583.1	lysine-specific histone demethylase 1A isoform c
XM_006710474.4	XP_006710537.1	lysine-specific histone demethylase 1A isoform X1
NM_001009999.3	NP_001009999.1	lysine-specific histone demethylase 1A isoform a
XM_006710473.4	XP_006710536.1	lysine-specific histone demethylase 1A isoform X3

KDM1A Protein Structure

SWIRM

Amino_oxidase

0
200
400
600
800
852 a.a.

Protein Preferred Names

Protein Names

lysine-specific histone demethylase 1A

BRAF35-HDAC complex protein BHC110	FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit
[histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A	amine oxidase (flavin containing) domain 2
flavin-containing amine oxidase domain-containing protein 2	lysine (K)-specific demethylase 1A
lysine-specific histone demethylase 1

Recombinant KDM1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75551	LSD1 Protein, Human (sf9, His-GST)	O60341-1 (S172-M852)	≥95%

Related Diseases

Diseases

Alias

Spherocytosis, Type 2

Hereditary Spherocytosis Type 2	SPH2
Spherocytosis, Hereditary, 2	Hs2
Hereditary Spherocytosis 2	Spherocytosis 2
Spherocytosis, Type 2, Autosomal Dominant

Cleft Palate, Psychomotor Retardation, And Distinctive Facial Features

Palatal Anomalies-Widely Spaced Teeth-Facial Dysmorphism-Developmental Delay Syndrome	CPRF
Palatal Anomalies-Multiple Diastemata-Facial Dysmorphism-Developmental Delay Syndrome

Rhabdomyosarcoma

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Leukemia, Myeloid, Acute	Acute Myeloid Leukemia, Somatic
Leukemia, Acute Myeloid, Somatic	Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic
Acute Myeloblastic Leukaemia	Acute Myelogenous Leukaemia
Aml - Acute Myeloid Leukemia	Acute Myeloid Leukemia With Cebpa Somatic Mutations
Aml With Cebpa Somatic Mutations	Inherited Acute Myeloid Leukemia
Familial Aml	Inherited Aml
Pure Familial Aml	Pure Familial Acute Myeloid Leukemia
Secondary Acute Myeloid Leukemia	Therapy-Related Aml And Myelodysplastic Syndrome
Acute Myeloid Leukemia, Secondary	Acute Non-Lymphoblastic Leukemia
Acute Non-Lymphocytic Leukemia	Acute Biphenotypic Leukemia
Acute Undifferentiated Leukemia	Acute Myeloblastic Leukaemia With Multilineage Dysplasia
Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission	Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Ewings Sarcoma	Ewing'S Sarcoma
Peripheral Neuroepithelioma	Primitive Neuroectodermal Tumor
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Extraosseous Ewing Tumor	Askin Tumor
Ewing'S Family Localized Tumor	Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing Sarcoma	Localized Ewing'S Sarcoma
Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing'S Tumor
Pnet Of Thoracopulmonary Region	Ewing Family Of Tumors
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Primary Hyperoxaluria

Hyperoxaluria, Primary	Oxalosis
Hyperoxaluria	Primary Oxalosis
Congenital Oxaluria	D-Glycerate Dehydrogenase Deficiency
Glyceric Aciduria	Glycolic Aciduria
Hepatic Agt Deficiency	Oxaluria, Primary
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Primary Oxaluria
Hyperoxaluria Primary	Primary Hyperoxaluria Type 2
Primary Hyperoxaluria, Type I

Cleft Palate, Cardiac Defects, And Mental Retardation

Cardiac Malformation, Cleft Lip/Palate, Microcephaly, And Digital Anomalies	CPCMR
Cleft Palate, Cardiac Defects, And Intellectual Disabillity	Cleft Palate, Cardiac Defects, And Intellectual Disability
Cardiac Malformation, Cleft Lip-Palate, Microcephaly And Digital Anomalies

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Desmoplastic/Nodular Medulloblastoma	Medulloblastoma With Extensive Nodularity
Desmoplastic Medulloblastoma	Medulloblastoma, Somatic
Medulloblastoma, Desmoplastic	Brain Medulloblastoma
Cns Pnet	Infratentorial Primitive Neuroectodermal Tumor
Mben	Medulloblastoma Desmoplastic
Neuroectodermal Tumors, Primitive	Medulloblastomas
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Kabuki Syndrome 1

Kabuki Syndrome	Niikawa-Kuroki Syndrome
Kabuki Make-Up Syndrome	Kms
KABUK1	Kabuki Make Up Syndrome
Nks	Kabuki Makeup Syndrome
Kabuki Syndrome, Type 1

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson-Gilford Disease
Hutchinson Gilford Progeria Syndrome	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-18632	GSK2879552	Inhibitor	99.75%	Phase 2
HY-103713	Seclidemstat	Inhibitor	99.77%	Phase 2
HY-18632A	GSK2879552 dihydrochloride	Inhibitor	99.52%	Phase 2
HY-12782T	Iadademstat dihydrochloride	Inhibitor	99.83%	Phase 1
HY-138830	TAK-418	Inhibitor	98.64%	Phase 1

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103713A	Seclidemstat mesylate	Inhibitor	99.86%	Unkown
HY-19612B	DDP-38003 trihydrochloride	Inhibitor	/	Unkown
HY-19612A	DDP-38003 dihydrochloride		98.21%	Unkown
HY-109117	Iadademstat	Inhibitor	/	Unkown
HY-112304	NCD38 TFA	Inhibitor	/	Unkown
HY-112304A	(1R,2S)-NCD38 TFA	Inhibitor	/	Unkown
HY-143238	FY-56	Inhibitor	/	Unkown
HY-RS07205	KDM1A Human Pre-designed siRNA Set A		/	Unkown
HY-RS07206	Kdm1a Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS07207	Kdm1a Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KDM1A	RGD	RGD:1562975
Canis familiaris	KDM1A	VGNC	VGNC:42318
Bos taurus	KDM1A	VGNC	VGNC:30522
Mus musculus	KDM1A	MGD	MGI:1196256
Macaca mulatta	KDM1A	VGNC	VGNC:73928
Felis catus	KDM1A	VGNC	VGNC:63067
Others	KDM1A	NCBI

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