SPICE1 - spindle and centriole associated protein 1 Gene

Also Known as SPICE; CCDC52

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 152185

About SPICE1

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:113,442,718-113,515,156 (from NCBI)

This gene has 7 transcripts (splice variants) and 181 orthologues. Ubiquitous expression in testis (RPKM 3.6), endometrium (RPKM 3.3) and 25 other tissues.

Summary

Involved in metaphase plate congression; mitotic spindle assembly; and regulation of centriole replication. Located in centriole; centrosome; and spindle. [provided by Alliance of Genome Resources, Apr 2022]

SPICE1 Products (4)

mRNA	Protein	Name
NM_001331078.2	NP_001318007.1	spindle and centriole-associated protein 1
NM_001331079.2	NP_001318008.2	spindle and centriole-associated protein 1
NM_001387939.1	NP_001374868.1	spindle and centriole-associated protein 1
NM_144718.4	NP_653319.1	spindle and centriole-associated protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23455924	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	20736305	GOA
involved in mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	20736305	GOA
involved in regulation of centriole replication	IMP IMP: Inferred from mutant phenotype	20736305	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centriole	IDA IDA: Inferred from direct assay	20736305	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in spindle	IDA IDA: Inferred from direct assay	20736305	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
spindle and centriole-associated protein 1	coiled-coil domain-containing protein 52

SPICE1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SPICE1	Q8N0Z3	CEP135	Homo sapiens	Q66GS9	BioID	26638075
Intra	SPICE1	Q8N0Z3	KDM1A	Homo sapiens	O60341	Y2H	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Arthrogryposis Multiplex Congenita-3
Ciliary Dyskinesia, Primary, 43	CILD43 Primary Ciliary Dyskinesia 43 Ciliary Dyskinesia, Primary, 43, With Or Without Situs Inversus Primary Ciliary Dyskinesia 43 With Or Without Situs Inversus Ciliary Dyskinesia, Primary, 43 With Or Without Situs Inversus
Blepharocheilodontic Syndrome 1	Blepharocheilodontic Syndrome Bcd Syndrome Elschnig Syndrome Clefting, Ectropion, And Conical Teeth Lagophthalmia With Bilateral Cleft Lip And Palate Blepharo-Cheilo-Odontic Syndrome Bcds Ectropion, Inferior, With Cleft Lip And/Or Palate Blepharo-Cheilo-Dontic Syndrome BCDS1 Ectropion Inferior Cleft Lip And Or Palate Clefting-Ectropion-Conical Teeth Syndrome Ectropion Inferior-Cleft Lip And/Or Palate Syndrome Lagophthalmia-Cleft Lip And Palate Syndrome Blepharocheilodontic Syndrome, Type 1
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS13673	SPICE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SPICE1	RGD	RGD:1310729
Canis familiaris	SPICE1	VGNC	VGNC:46740
Mus musculus	SPICE1	MGD	MGI:1196252
Bos taurus	SPICE1	VGNC	VGNC:35215
Felis catus	SPICE1	VGNC	VGNC:102848
Macaca mulatta	SPICE1	VGNC	VGNC:82732
Others	SPICE1	NCBI