RCOR2 - REST corepressor 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 283248

About RCOR2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:63,911,230-63,927,762 (from NCBI)

This gene has 3 transcripts (splice variants), 186 orthologues and 5 paralogues. Broad expression in brain (RPKM 4.9), testis (RPKM 1.7) and 14 other tissues.

Summary

Predicted to enable transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex and transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]

RCOR2 Products (2)

mRNA Protein Name
NM_001363648.2 NP_001350577.1 REST corepressor 2 isoform 2
NM_173587.4 NP_775858.2 REST corepressor 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24726434 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RCOR2 Protein Structure

ELM2

ELM2: ELM2 domain (46 - 99)

Myb_DNA-binding

Myb_DNA-binding: Myb-like DNA-binding domain (330 - 374)

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  • 523 a.a.
Protein Preferred Names Protein Names

REST corepressor 2

RCOR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RCOR2 Q8IZ40 KDM1A Homo sapiens O60341
Anti Bait CoIP
24726434
Intra
RCOR2 Q8IZ40 KDM1A Homo sapiens O60341
Anti Bait CoIP
28420882
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11792 RCOR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22773 Rcor2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29287 Rcor2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RCOR2 MGD MGI:1859854
Canis familiaris RCOR2 VGNC VGNC:45447
Rattus norvegicus RCOR2 RGD RGD:1359467
Macaca mulatta RCOR2 VGNC VGNC:76847
Felis catus RCOR2 VGNC VGNC:64552
Bos taurus RCOR2 VGNC VGNC:33835
Others RCOR2 NCBI