GSC - goosecoid homeobox Gene

Also Known as SAMS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 145258

About GSC

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:94,768,223-94,770,113 (from NCBI)

This gene has 1 transcript (splice variant), 189 orthologues, 50 paralogues and is associated with 2 phenotypes. Biased expression in fat (RPKM 1.7), brain (RPKM 0.2) and 8 other tissues.

Summary

This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq, Jul 2008]

GSC Products (1)

mRNA Protein Name
NM_173849.3 NP_776248.1 homeobox protein goosecoid

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in neural crest cell fate specification IMP
IMP: Inferred from mutant phenotype
24290375 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSC Protein Structure

Homeobox

Homeobox: Homeobox domain (161 - 217)

  • 0
  • 100
  • 200
  • 257 a.a.
Protein Preferred Names Protein Names

homeobox protein goosecoid

GSC Antibodies

Cat. No. Product Name Application Reactivity
HY-P82363 GSC Antibody (YA2108) WB, IP Human

Related Diseases

Diseases Alias
Short Stature, Auditory Canal Atresia, Mandibular Hypoplasia, And Skeletal Abnormalities

  • Short Stature, Auditory Canal Atresia, Mandibular Hypoplasia, Skeletal Abnormalities

  • Short Stature-Auditory Canal Atresia-Mandibular Hypoplasia-Skeletal Anomalies Syndrome

  • SAMS

  • Sams Syndrome

  • Stature, Short, Auditory Canal Atresia, Mandibular Hypoplasia, Skeletal Abnormalities
Fraser Syndrome 1

  • Fraser Syndrome

  • Cryptophthalmos With Other Malformations

  • Cryptophthalmos Syndrome

  • FRASRS1

  • Cryptophthalmos-Syndactyly Syndrome

  • Fraser-Francois Syndrome

  • Cyclopism

  • Meyer-Schwickerath'S Syndrome

  • Ulrich-Feichtiger Syndrome

  • Cryptophthalmos Syndactyly Syndrome

  • Fraser'S Syndrome

  • Meyer-Schwickerath Syndrome

  • Ullrich-Feichtiger Syndrome
Synostosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0292A Atracurium besylate Inhibitor 98.64% Unkown
HY-B0292 Atracurium Antagonist / Unkown

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110266 GN44028 Inhibitor 99.60% Unkown
HY-P2271 MM 54 Inhibitor 99.62% Unkown
HY-150082 CP681301 Inhibitor 99.18% Unkown
HY-117651 2-Fluoropalmitic acid Inhibitor 98.0% Unkown
HY-13768S1 Topotecan-d6 94.0% Unkown
HY-13768S Topotecan-d5 / Unkown
HY-171172 GSC-718 Inhibitor / Unkown
HY-173369 PROTAC MAGL degrader-1 Degrader / Unkown
HY-174212 MXC-017 Inducer / Unkown
HY-RS05852 GSC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05853 GSC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-159093 Antitumor agent-178 / Unkown
HY-RS18217 Gsc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24694 Gsc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GSC MGD MGI:95841
Bos taurus GSC VGNC VGNC:29672
Canis familiaris GSC VGNC VGNC:41525
Felis catus GSC VGNC VGNC:104397
Macaca mulatta GSC VGNC VGNC:108303
Rattus norvegicus GSC RGD RGD:631425
Others GSC NCBI